Literature DB >> 1433008

Antiphospholipid antibodies require beta 2-glycoprotein I (apolipoprotein H) as cofactor.

J V Jones1, H James, M H Tan, M Mansour.   

Abstract

IgG was isolated from 9 patients with high levels of anticardiolipin antibodies (aCL). The standard ELISA was modified, using gelatin to postcoat ELISA plates and as diluent. Under these conditions, 8/9 samples of IgG bound to cardiolipin only in the presence of a cofactor, found in fetal calf serum and normal human serum (NHS). beta 2-glycoprotein I (apolipoprotein H) was at least as effective as NHS as a cofactor for 7/9 IgG samples. Our studies confirm that for some aCL detected in conventional assays, the antibody will react with cardiolipin only if beta 2-glycoprotein I is present.

Entities:  

Mesh：

Substances：

Year:  1992        PMID： 1433008

Source DB:  PubMed          Journal:  J Rheumatol        ISSN： 0315-162X            Impact factor:   4.666


  13 in total

Review 1.  Antigenic specificities of "antiphospholipid" autoantibodies.

Authors:  R A Roubey
Journal:  Springer Semin Immunopathol       Date:  1994

Review 2.  Physiopathology of thrombosis induced by antiphospholipid antibodies.

Authors:  J M Zini
Journal:  Clin Rev Allergy Immunol       Date:  1995       Impact factor: 8.667

Review 3.  Antiphospholipid antibodies and the antiphospholipid syndrome.

Authors:  E N Harris; S S Pierangeli
Journal:  Springer Semin Immunopathol       Date:  1994

4.  Conformationally altered beta 2-glycoprotein I is the antigen for anti-cardiolipin autoantibodies.

Authors:  L W Chamley; A M Duncalf; B Konarkowska; M D Mitchell; P M Johnson
Journal:  Clin Exp Immunol       Date:  1999-03       Impact factor: 4.330

5.  A monoclonal IgG anticardiolipin antibody from a patient with the antiphospholipid syndrome is thrombogenic in mice.

Authors:  T Olee; S S Pierangeli; H H Handley; D T Le; X Wei; C J Lai; J En; W Novotny; E N Harris; V L Woods; P P Chen
Journal:  Proc Natl Acad Sci U S A       Date:  1996-08-06       Impact factor: 11.205

6.  Heterogeneity of the apolipoprotein H*3 allele and its role in affecting the binding of apolipoprotein H (beta 2-glycoprotein I) to anionic phospholipids.

Authors:  M I Kamboh; D R Wagenknecht; J A McIntyre
Journal:  Hum Genet       Date:  1995-04       Impact factor: 4.132

7.  Comprehensive evaluation of apolipoprotein H gene (APOH) variation identifies novel associations with measures of lipid metabolism in GENOA.

Authors:  Magalie S Leduc; Lawrence C Shimmin; Kathy L E Klos; Craig Hanis; Eric Boerwinkle; James E Hixson
Journal:  J Lipid Res       Date:  2008-08-01       Impact factor: 5.922

8.  Recombinant hepatitis B surface antigen and anionic phospholipids share a binding region in the fifth domain of beta2-glycoprotein I (apolipoprotein H).

Authors:  Haider Mehdi; Asma Naqvi; M Ilyas Kamboh
Journal:  Biochim Biophys Acta       Date:  2008-01-12

9.  Apolipoprotein H promoter polymorphisms in relation to lupus and lupus-related phenotypes.

Authors:  Sangita Suresh; F Yesim K Demirci; Erin Jacobs; Amy H Kao; Elisa Y Rhew; Dharambir K Sanghera; Faith Selzer; Kim Sutton-Tyrrell; David McPherson; Franklin A Bontempo; Candace M Kammerer; Rosalind Ramsey-Goldman; Susan Manzi; M Ilyas Kamboh
Journal:  J Rheumatol       Date:  2009-02       Impact factor: 4.666

10.  Detection of anti-bovine beta 2-glycoprotein I antibody in sera from patients with antiphospholipid syndrome.

Authors:  M Nomura; J Okada; H Kondo
Journal:  Rheumatol Int       Date:  1995       Impact factor: 2.631
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.