Literature DB >> 14329438

IMMUNITY IN EXPERIMENTAL SYPHILIS. 3. ATTENUATION OF VIRULENT TREPONEMA PALLIDIUM BY GAMMA-IRRADIATION.

J N MILLER.   

Abstract

Miller, James N. (University of California School of Medicine, Los Angeles). Immunity in experimental syphilis. III. Attenuation of virulent Treponema pallidum by gamma-irradiation. J. Bacteriol. 90:297-301. 1965.-Virulent, freshly isolated cells of Treponema pallidum strain Nichols suspended in a 50% rabbit serum-saline solution and exposed to a gamma-irradiation dosage of 652,800 r were rendered noninfectious without apparent loss of motility or change in observable morphological and staining characteristics. Although 5 x 10(7) gamma-irradiated organisms failed to elicit an immobilizing antibody response in rabbits, the same organisms retained their capacity to react with classical T. pallidum-immobilizing antibody.

Entities:  

Keywords:  ANTIGEN-ANTIBODY REACTIONS; EXPERIMENTAL LAB STUDY; IMMUNITY; RABBITS; RADIATION EFFECTS; STAINS AND STAINING; SYPHILIS; TREPONEMA IMMOBILIZATION TEST; TREPONEMA PALLIDUM; VIRULENCE

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Substances：

Year:  1965        PMID： 14329438      PMCID： PMC315641          DOI： 10.1128/jb.90.2.297-301.1965

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  8 in total

1.  IMMUNOGENICITY OF GAMMA-IRRADIATED MYCOBACTERIUM TUBERCULOSIS H37RV (GIV) IN MICE.

Authors:  H NISHIHARA; C A LAWRENCE; G V TAPLIN; C M CARPENTER
Journal:  Am Rev Respir Dis       Date:  1963-12

2.  STUDIES ON IMMUNITY IN EXPERIMENTAL SYPHILIS. II. TREPONEMA PALLIDUM IMMOBILIZATION (TPI) ANTIBODY AND THE IMMUNE RESPONSE.

Authors:  J N MILLER; F P FAZZAN; S J WHANG
Journal:  Br J Vener Dis       Date:  1963-09

3.  STUDIES ON IMMUNITY IN EXPERIMENTAL SYPHILIS. I. IMMUNOLOGIC RESPONSE OF RABBITS IMMUNIZED WITH REITER PROTEIN ANTIGEN AND CHALLENGED WITH VIRULENT TREPONEMA PALLIDUM.

Authors:  J N MILLER; S J WHANG; F P FAZZAN
Journal:  Br J Vener Dis       Date:  1963-09

4.  Sensitivity of the Treponema pallidum immobilization (TPI) test; a function of the number of spirochaetes in the antigen.

Authors:  J N MILLER; R A BOAK; C M CARPENTER
Journal:  Br J Vener Dis       Date:  1958-12

5.  A simple medium for maintaining the viability of Treponema pallidum in the Treponema pallidum immobilization test.

Authors:  R A BOAK; J N MILLER
Journal:  Am J Syph Gonorrhea Vener Dis       Date:  1954-09

6.  Antigenicity in rabbits and relation to immunity.

Authors:  Charlotte P McLeod
Journal:  Public Health Rep       Date:  1962-05       Impact factor: 2.792

7.  Further attempts to immunize rabbits with killed Treponema pallidum.

Authors:  G W WARING; W L FLEMING
Journal:  Am J Syph Gonorrhea Vener Dis       Date:  1951-11

8.  The relationship of treponemal immobilizing antibody to immunity in syphilis.

Authors:  T B TURNER; R A NELSON
Journal:  Trans Assoc Am Physicians       Date:  1950
  8 in total
  5 in total

1.  Editorial: Vaccines for syphilis.

Authors: 
Journal:  Br Med J       Date:  1974-05-18

2.  Immunological studies on treponemal cellular antigens. I. Serological changes and resistance to infection in rabbits immunized with treponemal nucleic acids.

Authors:  N N Izzat; E Yazdi
Journal:  Br J Vener Dis       Date:  1973-08

3.  Attempts at immunization against syphilis with avirulent Treponemma pallidum.

Authors:  N N Izzat; W G Dacres; J M Knox; R Wende
Journal:  Br J Vener Dis       Date:  1970-12

4.  Antigenic structure of Treponema pallidum, Nichols strain. II. Extraction of a polysaccharide antigen with "strain-specific" serological activity.

Authors:  J N Miller; J H Bekker; J H DeBruijn; P C Onvlee
Journal:  J Bacteriol       Date:  1969-07       Impact factor: 3.490

5.  Immunity in experimental syphilis. IV. Serological reactivity of antigens extracted from gamm-irradiated Treponema pallidum and Treponema reiteri.

Authors:  J N Miller; J H de Bruijn; J H Bekker
Journal:  J Bacteriol       Date:  1966-02       Impact factor: 3.490
  5 in total

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