| Literature DB >> 14325158 |
Abstract
Substrate induction of tryptophan pyrrolase in the liver of rats is inhibited by prior treatment of very young rats with tryptophan. This inhibition seems analogous to immunological tolerance, which can be produced by prior treatment with the antigen. The findings prowide support for an analogy between mechanisms of adaptive enzyme synthesis and those involved in adaptive immunity.Entities:
Keywords: ENZYME INHIBITORS; EXPERIMENTAL LAB STUDY; IMMUNE TOLERANCE; IMMUNITY; METABOLISM; OXYGENASES; RATS; TRYPTOPHAN; TRYPTOPHAN OXYGENASE
Mesh：
Substances：
Year: 1965 PMID： 14325158 DOI： 10.1126/science.149.3683.548
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728