Literature DB >> 14325156

CIRCADIAN RHYTHM IN PINEAL SEROTONIN: EFFECT OF MONOAMINE OXIDASE INHIBITION AND RESERPINE.

S H SNYDER, J AXELROD.   

Abstract

The pineal gland of the rat shows a circadian rhythm in its serotonin content, the amount of serotonin decreasing at night. This decrease can be prevented by inhibiting the action of monoamine oxidase. Reserpine abolishes the circadian rhythm in pineal serotonin in the same manner as does interruption of the sympathetic nervous connections of the central nervous system and the pineal gland. These observations suggest that circadian changes in release and binding of serotonin may occur in the pineal gland, and that a central mechanism in which monoamines participate may control the circadian pineal-serotonin rhythm.

Entities:  

Keywords:  CIRCADIAN RHYTHM; EXPERIMENTAL LAB STUDY; METABOLISM; MONOAMINE OXIDASE INHIBITORS; PERIODICITY; PHARMACOLOGY; PHENYLHYDRAZINE; PINEAL BODY; RATS; RESERPINE; SEROTONIN

Mesh：

Substances：

Year:  1965        PMID： 14325156     DOI： 10.1126/science.149.3683.542

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  13 in total

1.  Effects of reserpine and p-chlorophenylalanine on the circadian rhythm of granulated vesicles in the pinealocytes of mice.

Authors:  M Krasovich; B Benson
Journal:  Cell Tissue Res       Date:  1979       Impact factor: 5.249

2.  The influence of some sympatholytic, parasympatholytic and serotonin-synthesis-inhibiting agents on the ultrastructure of the rabbit pineal organ.

Authors:  H J Romijn
Journal:  Cell Tissue Res       Date:  1976-03-16       Impact factor: 5.249

3.  Diurnal variation in norepinephrine-stimulated release of pineal serotonin in vitro.

Authors:  B Benson; W D Reynolds; D M Burns; C A Leadem
Journal:  J Neural Transm Gen Sect       Date:  1989

4.  Circadian 5-HT production regulated by adrenergic signaling.

Authors:  Xing Sun; Jie Deng; Tiecheng Liu; Jimo Borjigin
Journal:  Proc Natl Acad Sci U S A       Date:  2002-03-26       Impact factor: 11.205

5.  Daily rhythmic changes in tyrosine transaminase activity of the rat liver.

Authors:  R J Wurtman; J Axelrod
Journal:  Proc Natl Acad Sci U S A       Date:  1967-06       Impact factor: 11.205

6.  Histochemical correlates of changes in the primate brain associated with varying environmental light conditions.

Authors:  S L Manocha; A A Perachio
Journal:  Histochemie       Date:  1973

7.  The mammalian pineal gland, a survey.

Authors:  J A Kappers
Journal:  Acta Neurochir (Wien)       Date:  1976       Impact factor: 2.216

8.  [A case of tranylcypromine and trifluoperazine (Jatrosom) addiction: psychopathological, sleep physiology and biochemical investigations].

Authors:  H Cramer; D Ohlmeier
Journal:  Arch Psychiatr Nervenkr (1970)       Date:  1967

9.  Day-night differences in estimated rates of 5-hydroxytryptamine turnover in the rat pineal gland.

Authors:  T S King; R W Steger; S Steinlechner; R J Reiter
Journal:  Exp Brain Res       Date:  1984       Impact factor: 1.972

10.  Rat brain amines, blood histamine and glucose levels in relationship to circadian changes in sleep induced by pentobarbitone sodium.

Authors:  A H Friedman; C A Walker
Journal:  J Physiol       Date:  1969-05       Impact factor: 5.182
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