Literature DB >> 14325155

CYCASIN: RADIOMIMETIC EFFECT.

H J TEAS, H SAX, K SAX.   

Abstract

Cycasin, methylazoxy-methanol-beta-glucoside, a carcinogenic compound that occurs naturally in cycad plants, induces chromosome aberrations in the root-tip cells of Allium cepa. Germination and growth in an aqueous solution of cycasin at a concentration of only 3 percent of that found in Cycas circinalis induced as many aberrations in chromosomes as did about 200 roentgens of gamma irradiation.

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Keywords:  CARCINOGENS; EXPERIMENTAL LAB STUDY; GLYCOSIDES; PHARMACOLOGY; PLANTS; RADIATION EFFECTS; TOXICOLOGIC REPORT

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Year:  1965        PMID: 14325155     DOI: 10.1126/science.149.3683.541

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  3 in total

1.  Radiomimetic beverages, drugs, and mutagens.

Authors:  K Sax; H J Sax
Journal:  Proc Natl Acad Sci U S A       Date:  1966-06       Impact factor: 11.205

2.  Studies on methylazoxymethanol, the aglycone of cycasin: methylation of nucleic acids in vitro.

Authors:  H Matsumoto; H H Higa
Journal:  Biochem J       Date:  1966-02       Impact factor: 3.857

3.  Hypothesis: Etiologic and Molecular Mechanistic Leads for Sporadic Neurodegenerative Diseases Based on Experience With Western Pacific ALS/PDC.

Authors:  Peter S Spencer
Journal:  Front Neurol       Date:  2019-07-31       Impact factor: 4.003

  3 in total

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