| Literature DB >> 14323664 |
Abstract
Extracts of human splenic tissue were found to resemble interferon in (a) their physicochemical properties, and (b) their mode of action when tested in vivo in the rabbit, using vaccinia as the challenge virus. The methods used to obtain (1) the crude extract and (2) a partially purified final fraction are described. The latter was found to be non-dialysable, stable over a pH range of 2-11, and relatively heat resistant. On analysis it appeared to be, or was associated with, a glycoprotein.Entities:
Keywords: ANTIVIRAL AGENTS; BIOLOGICAL PRODUCTS; CARBOHYDRATES; CHEMISTRY; CHEMISTRY, ANALYTICAL; EXPERIMENTAL LAB STUDY; HEAT; HYDROGEN-ION CONCENTRATION; INTERFERON; PROTEINS; RABBITS; SPLEEN; TISSUE EXTRACTS; VACCINIA VIRUS
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Year: 1965 PMID： 14323664 PMCID： PMC1928599
Source DB: PubMed Journal: Can Med Assoc J ISSN： 0008-4409 Impact factor: 8.262