| Literature DB >> 1432159 |
U Haberkorn1, M Reinhardt, L G Strauss, F Oberdorfer, M R Berger, A Altmann, R Wallich, A Dimitrakopoulou, G van Kaick.
Abstract
In order to quantify effects of an experimental chemotherapy, MCF7 cells were studied with 14C-fluorodeoxyglucose (FDG) and high-performance liquid chromatography (HPLC). Uptake measurements were performed 1 and 4 hr after the end of a therapy with hexadecylphosphocholine (HPC). A dose- and time-dependent increase of the FDG uptake after therapy was observed, with a maximum at 1 hr after therapy. These data were used to develop a new metabolic design of combination treatment. Several time-dose combinations of HPC and deoxyglucose (DOG) were analyzed for their effects on growth inhibition. The combinations using DOG in the period of pronounced enhancement of FDG uptake (1 hr after HPC treatment) were found to be the most effective with an improvement of up to 520% in growth inhibition. This metabolic design of combination treatment may also be applied in vivo, and PET can be used to optimize the time and dose schedule of the modified treatment protocol.Entities:
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Year: 1992 PMID： 1432159
Source DB: PubMed Journal: J Nucl Med ISSN： 0161-5505 Impact factor: 10.057