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Literature DB >> 14316945

EFFECT OF 6-MERCAPTOPURINE (6-MP) ON DIFFERENT CLASSES OF ANTIBODY.

Abstract

In the primary response of mice and rabbits immunized with foreign red cells, 6-MP administration prolonged the formation of 19S antibody. 7S antibody formation was delayed and reduced in these animals. Animals treated with 6-MP during primary response exhibited a preferential 19S response when challenged in the anamnestic response. Animals immunized with small doses of antigen and treated with 6-MP only during the secondary response, reversed the usual antibody pattern and responded with preferential 19S antibody formation.

Entities: Chemical Species

Keywords: ANTIBODIES; ANTIBODY FORMATION; ANTIGENS; CHROMATOGRAPHY; EXPERIMENTAL LAB STUDY; GAMMA GLOBULIN, 19S; GAMMA GLOBULIN, 7S; MERCAPTOPURINE; MICE; PHARMACOLOGY; RABBITS; ULTRACENTRIFUGATION

Mesh：

Substances：

Year: 1965 PMID： 14316945 PMCID： PMC2138064 DOI： 10.1084/jem.122.2.263

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

8 in total

Review 1. THE HETEROGENEITY OF THE IMMUNE RESPONSE.

Authors: J W UHR
Journal: Science Date: 1964-07-31 Impact factor: 47.728

2. INHIBITION OF 19S ANTIBODY SYNTHESIS BY 7S ANTIBODY.

Authors: K SAHIAR; R S SCHWARTZ
Journal: Science Date: 1964-07-24 Impact factor: 47.728

3. THE EFFECT OF 6-MERCAPTOPURINE ON IMMUNE RESPONSE IN MAN.

Authors: R H LEVIN; M LANDY; E FREI
Journal: N Engl J Med Date: 1964-07-02 Impact factor: 91.245

4. 7S VERSUS 19S ANAMNESTIC RESPONSE IN RABBITS.

Authors: Y BOREL; M FAUCONNET; P A MIESCHER
Journal: Proc Soc Exp Biol Med Date: 1964-11

5. The treatment of autoimmune hemolytic anemia with 6-mercaptopurine and thioguanine.

Authors: R SCHWARTZ; W DAMESHEK
Journal: Blood Date: 1962-04 Impact factor: 22.113

6. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

7. Interaction of the rheumatoid factor with antigen-antibody complexes and aggregated gamma globulin.

Authors: G M EDELMAN; H G KUNKEL; E C FRANKLIN
Journal: J Exp Med Date: 1958-07-01 Impact factor: 14.307

8. THE IMMUNOGLOBULINS OF MICE. I. FOUR MAJOR CLASSES OF IMMUNOGLOBULINS: 7S GAMMA-2-, 7S GAMMA-1-, GAMMA-1A (BETA-2A)-, AND 18S GAMMA-1M-GLOBULINS.

Authors: J L FAHEY; J WUNDERLICH; R MISHELL
Journal: J Exp Med Date: 1964-08-01 Impact factor: 14.307

8 in total

16 in total

1. Characterization of the impaired antipneumococcal polysacharide antibody production in immunosuppressed pediatric patients following cardiac transplantation.

Authors: A R Gennery; A J Cant; C I Baldwin; J E Calvert
Journal: J Clin Immunol Date: 2001-01 Impact factor: 8.317

2. Inverse effect on the serum levels of gamma-G- and gamma-M-globulins after prednisone treatment of lupoid hepatitis.

Authors: F A Wollheim
Journal: Clin Exp Immunol Date: 1967-07 Impact factor: 4.330

Review 3. Suppression of the immune response.

Authors: J Bradley; C J Elson
Journal: J Med Genet Date: 1971-09 Impact factor: 6.318

4. The effect of unaggregated bovine gamma globulin on gamma M and gamma G antibody formation.

Authors: Y Borel; E C Franklin; P A Miescher
Journal: Immunology Date: 1968-06 Impact factor: 7.397

5. The effect of single large dose hydrocortisone treatment on IgM and IgG antibody production, morphological distribution of antibody producing cells and immunological memory.

Authors: G Petrányi; M Benczúr; P Alföldy
Journal: Immunology Date: 1971-07 Impact factor: 7.397