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Literature DB >> 14293004

UNSTABLE LINKAGE BETWEEN GENETIC MARKERS IN TRANSFORMATION.

Abstract

Kelly, M. (Hammersmith Hospital, London, England), and R. H. Pritchard. Unstable linkage between genetic markers in transformation. J. Bacteriol. 89:1314-1321. 1965.-A new type of association of genetic markers in a transformation system has been discovered. Linkage between certain markers is detectable only under particular conditions of deoxyribonucleic acid (DNA) extraction and is sensitive to dilution of the DNA. The data suggest that this unstable association occurs between markers which are on the same molecule but separated by a molecular distance sufficiently great for linkage to be preserved only by mild DNA extraction procedures and at high concentrations of DNA. Linkage can be stabilized by dilution in the presence of a carrier DNA. By use of these unstable linkages, the genetic map of Bacillus subtilis has been extended in both directions from the aromatic gene cluster.

Entities: Species

Keywords: BACILLUS SUBTILIS; CHROMOSOME MAPPING; DNA, BACTERIAL; EXPERIMENTAL LAB STUDY; GENES; GENETICS; PHARMACOLOGY

Mesh：

Substances：

Year: 1965 PMID： 14293004 PMCID： PMC277646 DOI： 10.1128/jb.89.5.1314-1321.1965

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

14 in total

1. Transformation studies on the linkage of markers in the tryptophan pathway in Bacillus subtilis.

Authors: C ANAGNOSTOPOULOS; I P CRAWFORD
Journal: Proc Natl Acad Sci U S A Date: 1961-03-15 Impact factor: 11.205

2. Sequential replication of Bacillus subtilis chromosome. I. Comparison of marker frequencies in exponential and stationary growth phases.

Authors: H YOSHIKAWA; N SUEOKA
Journal: Proc Natl Acad Sci U S A Date: 1963-04 Impact factor: 11.205

3. Sequential replication of the Bacillus subtilis chromosome. II. Isotopic transfer experiments.

Authors: H YOSHIKAWA; N SUEOKA
Journal: Proc Natl Acad Sci U S A Date: 1963-06 Impact factor: 11.205

4. Mutation of bacteria at high levels of survival by ethyl methane sulphonate.

Authors: A LOVELESS; S HOWARTH
Journal: Nature Date: 1959-12-05 Impact factor: 49.962

5. A new method for the isolation of deoxyribonucleic acids; evidence on the nature of bonds between deoxyribonucleic acid and protein.

Authors: K S KIRBY
Journal: Biochem J Date: 1957-07 Impact factor: 3.857

6. A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.

Authors: K BURTON
Journal: Biochem J Date: 1956-02 Impact factor: 3.857

UNSTABLE LINKAGE BETWEEN GENETIC MARKERS IN TRANSFORMATION.

1. Transformation studies on the linkage of markers in the tryptophan pathway in Bacillus subtilis.

2. Sequential replication of Bacillus subtilis chromosome. I. Comparison of marker frequencies in exponential and stationary growth phases.

3. Sequential replication of the Bacillus subtilis chromosome. II. Isotopic transfer experiments.

4. Mutation of bacteria at high levels of survival by ethyl methane sulphonate.

5. A new method for the isolation of deoxyribonucleic acids; evidence on the nature of bonds between deoxyribonucleic acid and protein.

6. A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.

7. REQUIREMENTS FOR TRANSFORMATION IN BACILLUS SUBTILIS.

8. TRANSFORMATION OF BIOCHEMICALLY DEFICIENT STRAINS OF BACILLUS SUBTILIS BY DEOXYRIBONUCLEATE.

9. Gene Linkage in DNA Transfer: A Cluster of Genes Concerned with Aromatic Biosynthesis in Bacillus Subtilis.

10. Chelation therapy in circulatory and sclerosing diseases.

1. Chromosomal basis of the merozygosity in a partially deploid mutant of Pneumococcus.

2. Physiological factors affecting transformation of Azotobacter vinelandii.

3. Genetic exchange in Bacillus subtilis in soil.

4. Transformation analysis of three linkage groups in Staphylococcus aureus.

Review 5. Linkage map of Salmonella typhimurium, edition IV.

6. Low frequency of co-integration of two linked streptomycin-resistance markers in Pneumococcus.

Review 7. Genetic transfer and bacterial taxonomy.

8. Pseudomonas stutzeri and related species undergo natural transformation.

9. Effect of deoxyribonucleic acid replication inhibitors on bacterial recombination.

10. LINKAGE RELATIONSHIPS OF GENES CONTROLLING ISOLEUCINE, VALINE, AND LEUCINE BIOSYNTHESIS IN BACILLUS SUBTILIS.