Literature DB >> 1429229

Lactimidomycin, a new glutarimide group antibiotic. Production, isolation, structure and biological activity.

K Sugawara1, Y Nishiyama, S Toda, N Komiyama, M Hatori, T Moriyama, Y Sawada, H Kamei, M Konishi, T Oki.   

Abstract

Streptomyces amphibiosporus R310-104 (ATCC 53964) produced a novel antibiotic lactimidomycin which showed inhibitory activity against fungi and prolonged the survival time of mice transplanted with experimental tumors. Structural studies clarified that lactimidomycin is a new glutarimide antibiotic having a unique unsaturated 12-membered lactone ring.

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Year:  1992        PMID： 1429229     DOI： 10.7164/antibiotics.45.1433

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  21 in total

1.  Translation Initiation Site Profiling Reveals Widespread Synthesis of Non-AUG-Initiated Protein Isoforms in Yeast.

Authors:  Amy R Eisenberg; Andrea L Higdon; Ina Hollerer; Alexander P Fields; Irwin Jungreis; Paige D Diamond; Manolis Kellis; Marko Jovanovic; Gloria A Brar
Journal:  Cell Syst       Date:  2020-07-24       Impact factor: 10.304

2.  Thermolysis of isomigrastatin and its congeners via [3,3]-sigmatropic rearrangement: a new route to the synthesis of migrastatin and its analogues.

Authors:  Jianhua Ju; Si-Kyu Lim; Hui Jiang; Jeong-Woo Seo; Yeng Her; Ben Shen
Journal:  Org Lett       Date:  2006-12-07       Impact factor: 6.005

3.  Garbled messages and corrupted translations.

Authors:  Tilman Schneider-Poetsch; Takeo Usui; Daisuke Kaida; Minoru Yoshida
Journal:  Nat Chem Biol       Date:  2010-03       Impact factor: 15.040

Review 4.  Broad-spectrum agents for flaviviral infections: dengue, Zika and beyond.

Authors:  Veaceslav Boldescu; Mira A M Behnam; Nikos Vasilakis; Christian D Klein
Journal:  Nat Rev Drug Discov       Date:  2017-05-05       Impact factor: 84.694

5.  Lactimidomycin is a broad-spectrum inhibitor of dengue and other RNA viruses.

Authors:  Margot Carocci; Priscilla L Yang
Journal:  Antiviral Res       Date:  2016-02-10       Impact factor: 5.970

6.  A Long-Range Acting Dehydratase Domain as the Missing Link for C17-Dehydration in Iso-Migrastatin Biosynthesis.

Authors:  Bo Zhang; Zhengren Xu; Qihui Teng; Guohui Pan; Ming Ma; Ben Shen
Journal:  Angew Chem Int Ed Engl       Date:  2017-05-19       Impact factor: 15.336

7.  Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin.

Authors:  Tilman Schneider-Poetsch; Jianhua Ju; Daniel E Eyler; Yongjun Dang; Shridhar Bhat; William C Merrick; Rachel Green; Ben Shen; Jun O Liu
Journal:  Nat Chem Biol       Date:  2010-01-31       Impact factor: 15.040

8.  Evaluation of new migrastatin and dorrigocin congeners unveils cell migration inhibitors with dramatically improved potency.

Authors:  Jianhua Ju; Scott R Rajski; Si-Kyu Lim; Jeong-Woo Seo; Noël R Peters; F Michael Hoffmann; Ben Shen
Journal:  Bioorg Med Chem Lett       Date:  2008-07-24       Impact factor: 2.823

9.  Lactimidomycin, iso-migrastatin and related glutarimide-containing 12-membered macrolides are extremely potent inhibitors of cell migration.

Authors:  Jianhua Ju; Scott R Rajski; Si-Kyu Lim; Jeong-Woo Seo; Noël R Peters; F Michael Hoffmann; Ben Shen
Journal:  J Am Chem Soc       Date:  2009-02-04       Impact factor: 15.419

10.  Global mapping of translation initiation sites in mammalian cells at single-nucleotide resolution.

Authors:  Sooncheol Lee; Botao Liu; Soohyun Lee; Sheng-Xiong Huang; Ben Shen; Shu-Bing Qian
Journal:  Proc Natl Acad Sci U S A       Date:  2012-08-27       Impact factor: 11.205
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