| Literature DB >> 1428913 |
S P Hume1, A A Lammertsma, C J Bench, V W Pike, C Pascali, J E Cremer, R J Dolan.
Abstract
The biologically active S-enantiomer of [N-methyl-11C]citalopram was evaluated as a radioligand for in vivo labelling of the 5-hydroxytryptamine uptake site in brain, using ex vivo tissue counting in rats and positron emission tomography in man. In rats, the maximal signal for total versus non-specific binding was approx. 2 at 60-120 min after radioligand injection. Subsequent studies in man failed to identify a specific signal over a 90 min scanning period, due to prolonged retention of non-specific label.Entities:
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Year: 1992 PMID： 1428913 DOI： 10.1016/0883-2897(92)90171-t
Source DB: PubMed Journal: Int J Rad Appl Instrum B ISSN： 0883-2897