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Literature DB >> 142838

Calcium dependent ATP losses in intact red blood cells without cellular accumulations of calcium.

Abstract

Intact human red blood cells incubated with ionophore A23187 and calcium develop a depletion of ATP that is dependent upon the concentrations of both A23187 and Ca. Incubations of fresh cells with 0.5 micrometer A23187 and concentrations of Ca at or below 70 micrometer produce a depletion of ATP without a net cellular uptake of Ca. In contrast, ATP-depleted cells display an ionophore-dependent cellular uptake of Ca, under identical conditions. A hypothesis is proposed that relates these ionophore-produced ATP depletions to active Ca extrusion by the Ca ATPase.

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Year: 1977 PMID： 142838 DOI： 10.1007/bf01869956

Source DB: PubMed Journal: J Membr Biol ISSN： 0022-2631 Impact factor: 1.843

11 in total

4. Effects of carvedilol on common carotid arterial flow, peripheral hemodynamics, and hemorheologic variables in hypertension.

Authors: Y Nagakawa; Y Akedo; S Kaku; H Orimo
Journal: Eur J Clin Pharmacol Date: 1990 Impact factor: 2.953

4 in total

Calcium dependent ATP losses in intact red blood cells without cellular accumulations of calcium.

1. A23187 and red cells: changes in deformability, K+, Mg-2+, Ca-2+ and ATP.

2. Proceedings: Ca transport and Ca pump reversal in human red blood cells.

3. Standardization of hemoglobinometry. II. The hemiglobincyanide method.

4. Effects of divalent cation ionophore A23187 on potassium permeability of rat erythrocytes.

5. Dependence on calcium concentration and stoichiometry of the calcium pump in human red cells.

6. A semiautomated procedure for determination of adenosine triphosphate.

7. Ouabain-insensitive effects of metabolism on ion and water content of red blood cells.

8. Use of ionophore A23187 to measure cytoplasmic Ca buffering and activation of the Ca pump by internal Ca.

9. The use of ionophores of rapid loading of human red cells with radioactive cations for cation-pump studies.

10. Role of calcium in volume regulation by dog red blood cells.

1. Effects of felodipine on red blood cell deformability.

2. The acute effects of nifedipine on red cell deformability in angina pectoris.

3. Separate mechanisms of deformability loss in ATP-depleted and Ca-loaded erythrocytes.

4. Effects of carvedilol on common carotid arterial flow, peripheral hemodynamics, and hemorheologic variables in hypertension.