Literature DB >> 1427998

In vitro bioassay for type E prostaglandins based on their NK immunodepressing activity.

T E Kluchareva1, V A Matveeva, N E Kushlinsky.   

Abstract

A biological assay for PGE in commercial preparations, or secreted by tumor cells in culture fluid was developed on the basis of the immunosuppressive effect of PGE on the cytotoxic activity of NK cells. The assay is simple, rapid and convenient for detecting PGE cell secretion, either spontaneous or induced by various signals. The sensitivity of the bioassay is limited by the sensitivity of NK cells to the immunosuppressive activity of PGE (i.e., about 10(-8) M).

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Year:  1992        PMID： 1427998     DOI： 10.1016/0165-2478(92)90068-y

Source DB:  PubMed          Journal:  Immunol Lett        ISSN： 0165-2478            Impact factor:   3.685


  2 in total

1.  Dynamics of natural selection of tumor cells for the [H2O2CA + PGES] marker phenotype during subcutaneous growth and dissemination.

Authors:  N A D'yakova; L M Kashkina; V A Matveeva; E N Uvarova; G I Deichman
Journal:  Dokl Biol Sci       Date:  2001 May-Jun

2.  Acquisition of HP phenotype and alterations in the activity of catalase of in vitro transformed cells of different origin in the dynamics of in vivo tumor progression.

Authors:  L M Kashkina; V A Matveeva; N A Dyakova; E N Uvarova; G I Deichman
Journal:  Dokl Biol Sci       Date:  2004 Jan-Feb
  2 in total

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