Literature DB >> 1427833

Organization of the human monoamine oxidase genes and long-range physical mapping around them.

Z Y Chen1, J F Powell, Y P Hsu, X O Breakefield, I W Craig.   

Abstract

A 265-kb yeast artificial chromosome containing sequences for human monoamine oxidase A and B (MAO-A and MAO-B) genes has been characterized. These two genes are localized within a region of about 240 kb and are arranged in a tail-to-tail configuration, with the 3' coding sequences separated by about 50 kb. A region about 2.5 Mb around the MAO loci was mapped by pulsed-field gel electrophoresis (PFGE). Comparisons between the restriction maps derived from the YAC and the long-range map derived from genomic digestions were in general agreement. The important features identified include a CpG island at the 5' end of the MAO-A and MAO-B genes, respectively. The combined information supports the order of markers within this region to be DXS77-DXS7-MAOA-MAOB.

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Year:  1992        PMID： 1427833     DOI： 10.1016/s0888-7543(05)80286-1

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  9 in total

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6.  Association study between monoamine oxidase A (MAOA) gene polymorphisms and schizophrenia: lack of association with schizophrenia and possible association with affective disturbances of schizophrenia.

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8.  Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA.

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  9 in total

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