Literature DB >> 1427665

Effect on the canine Eck fistula liver of intraportal TGF-beta alone or with hepatic growth factors.

A Francavilla1, A Azzarone, G Carrieri, C Scotti-Foglieni, Q H Zeng, U Cillo, K Porter, T E Starzl.   

Abstract

Transforming growth factor-beta canceled the hepatocyte proliferation caused by transforming growth factor-alpha when the two substances were mixed and administered through a disconnected central portal vein branch after creation of an Eck fistula. In contrast, transforming growth factor-beta had no antidotal action on the stimulatory effects of insulin or full test doses of insulinlike factor-2, hepatocyte growth factor, epidermal growth factor or triiodothymanine. A minor antidotal effect on hepatic stimulatory substance activity could be detected, but only with hepatic stimulatory substance was given in doses smaller than those known to cause maximum stimulatory response. These results suggest a highly specific pharmacological and physiological interaction between transforming growth factor-alpha and transforming growth factor-beta in the modulation of liver growth control.

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Year:  1992        PMID： 1427665      PMCID： PMC2954644     

Source DB:  PubMed          Journal:  Hepatology        ISSN： 0270-9139            Impact factor:   17.425


  20 in total

1.  Hepatotrophic effects of FK506 in dogs.

Authors:  T E Starzl; K A Porter; V Mazzaferro; S Todo; J Fung; A Francavilla
Journal:  Transplantation       Date:  1991-01       Impact factor: 4.939

2.  Hepatotrophic properties in dogs of human FKBP, the binding protein for FK506 and rapamycin.

Authors:  T E Starzl; S L Schreiber; M W Albers; K A Porter; C S Foglieni; A Francavilla
Journal:  Transplantation       Date:  1991-10       Impact factor: 4.939

3.  Altered responses of regenerating hepatocytes to norepinephrine and transforming growth factor type beta.

Authors:  K A Houck; G K Michalopoulos
Journal:  J Cell Physiol       Date:  1989-12       Impact factor: 6.384

4.  The origin, hormonal nature, and action of hepatotrophic substances in portal venous blood.

Authors:  T E Starzl; A Francavilla; C G Halgrimson; F R Francavilla; K A Porter; T H Brown; C W Putnam
Journal:  Surg Gynecol Obstet       Date:  1973-08

Review 5.  Liver regeneration: molecular mechanisms of growth control.

Authors:  G K Michalopoulos
Journal:  FASEB J       Date:  1990-02-01       Impact factor: 5.191

6.  Transforming growth factor receptors in liver regeneration following partial hepatectomy in the rat.

Authors:  P A Gruppuso; J E Mead; N Fausto
Journal:  Cancer Res       Date:  1990-03-01       Impact factor: 12.701

7.  The hepatotropic influence of cyclosporine.

Authors:  V Mazzaferro; K A Porter; C L Scotti-Foglieni; R Venkataramanan; L Makowka; L Rossaro; A Francavilla; S Todo; D H Van Thiel; T E Starzl
Journal:  Surgery       Date:  1990-05       Impact factor: 3.982

8.  Effects of insulin, glucagon, and insuling/glucagon infusions on liver morphology and cell division after complete portacaval shunt in dogs.

Authors:  T E Starzl; K Watanabe; K A Porter; C W Putnam
Journal:  Lancet       Date:  1976-04-17       Impact factor: 79.321

9.  Transforming growth factor alpha may be a physiological regulator of liver regeneration by means of an autocrine mechanism.

Authors:  J E Mead; N Fausto
Journal:  Proc Natl Acad Sci U S A       Date:  1989-03       Impact factor: 11.205

10.  Screening for candidate hepatic growth factors by selective portal infusion after canine Eck's fistula.

Authors:  A Francavilla; T E Starzl; K Porter; C S Foglieni; G K Michalopoulos; G Carrieri; J Trejo; A Azzarone; M Barone; Q H Zeng
Journal:  Hepatology       Date:  1991-10       Impact factor: 17.425
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  6 in total

1.  Hepatic stimulator substance activity in animal model of fulminant hepatic failure and encephalopathy.

Authors:  Alexandra P Margeli; Evangelos Manolis; Spyridon N Skaltsas; Kyriakos S Tsarpalis; Michael G Mykoniatis; Stamatios E Theocharis
Journal:  Dig Dis Sci       Date:  2002-10       Impact factor: 3.199

Review 2.  Insights on augmenter of liver regeneration cloning and function.

Authors:  Elisavet Gatzidou; Gregory Kouraklis; Stamatios Theocharis
Journal:  World J Gastroenterol       Date:  2006-08-21       Impact factor: 5.742

3.  A fresh look at augmenter of liver regeneration in rats.

Authors:  C R Gandhi; R Kuddus; V M Subbotin; J Prelich; N Murase; A S Rao; M A Nalesnik; S C Watkins; A DeLeo; M Trucco; T E Starzl
Journal:  Hepatology       Date:  1999-05       Impact factor: 17.425

4.  The in vivo effect of hepatotrophic factors augmenter of liver regeneration, hepatocyte growth factor, and insulin-like growth factor-II on liver natural killer cell functions.

Authors:  A Francavilla; N L Vujanovic; L Polimeno; A Azzarone; A Iacobellis; A Deleo; M Hagiya; T L Whiteside; T E Starzl
Journal:  Hepatology       Date:  1997-02       Impact factor: 17.425

5.  Portacaval shunt causes apoptosis and liver atrophy in rats despite increases in endogenous levels of major hepatic growth factors.

Authors:  Chandrashekhar R Gandhi; Noriko Murase; Vladimir M Subbotin; Tadahiro Uemura; Michael Nalesnik; Anthony J Demetris; John J Fung; Thomas E Starzl
Journal:  J Hepatol       Date:  2002-09       Impact factor: 25.083

6.  Cloning and sequence analysis of the rat augmenter of liver regeneration (ALR) gene: expression of biologically active recombinant ALR and demonstration of tissue distribution.

Authors:  M Hagiya; A Francavilla; L Polimeno; I Ihara; H Sakai; T Seki; M Shimonishi; K A Porter; T E Starzl
Journal:  Proc Natl Acad Sci U S A       Date:  1994-08-16       Impact factor: 11.205
  6 in total

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