Literature DB >> 1427006

Antitubercular activity of trifluoperazine, a calmodulin antagonist.

P Ratnakar1, P S Murthy.   

Abstract

Trifluoperazine, a calmodulin antagonist, completely inhibited the growth of mycobacteria. The minimum inhibitory concentrations in shake cultures in a synthetic medium containing 0.2% Tween 80 were 5 and 8 micrograms/ml, respectively, for the human pathogenic strain Mycobacterium tuberculosis H37Rv and M. tuberculosis resistant to isoniazid. When added to a growing culture of M. tuberculosis H37Rv on the 10th day (mid exponential phase), trifluoperazine 50 micrograms/ml further arrested growth of this organism. It is suggested that trifluoperazine or similar calmodulin antagonists might be useful as antitubercular drugs.

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Year:  1992        PMID： 1427006     DOI： 10.1016/0378-1097(92)90366-v

Source DB:  PubMed          Journal:  FEMS Microbiol Lett        ISSN： 0378-1097            Impact factor:   2.742


  8 in total

1.  Inhibitors of type II NADH:menaquinone oxidoreductase represent a class of antitubercular drugs.

Authors:  Edward A Weinstein; Takahiro Yano; Lin-Sheng Li; David Avarbock; Andrew Avarbock; Douglas Helm; Andrew A McColm; Ken Duncan; John T Lonsdale; Harvey Rubin
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-14       Impact factor: 11.205

Review 2.  Thioridazine: resurrection as an antimicrobial agent?

Authors:  H K R Thanacoody
Journal:  Br J Clin Pharmacol       Date:  2007-08-31       Impact factor: 4.335

3.  A Mycobacterium tuberculosis sigma factor network responds to cell-envelope damage by the promising anti-mycobacterial thioridazine.

Authors:  Noton K Dutta; Smriti Mehra; Deepak Kaushal
Journal:  PLoS One       Date:  2010-04-08       Impact factor: 3.240

4.  Antitubercular activity of garlic (allium sativum) extract on combination with conventional antitubercular drugs in tubercular lymphadenitis.

Authors:  R L Gupta; S Jain; V Talwar; H C Gupta; P S Murthy
Journal:  Indian J Clin Biochem       Date:  1999-01

5.  Studies on a new antitubercular drug, trifluoperazine: Its effect in combination with conventional antitubercular drugs in tubercular lymphadenitis.

Authors:  R L Gupta; S Jain; V Talwar; H C Gupta; P S Murthy
Journal:  Indian J Clin Biochem       Date:  1998-07

6.  Trifluoperazine and CEF-allicin from garlic (Allium sativum) as potential new antitubercular drugs active against drug resistantMycobacterium tuberculosis.

Authors:  P S Murthy; P Ratnakar; D V Gadre; V Talwar; H C Gupta; R L Gupta
Journal:  Indian J Clin Biochem       Date:  1997-12

7.  Cloning and expression of the gene for a novel protein from Mycobacterium smegmatis with functional similarity to eukaryotic calmodulin.

Authors:  Prasad T Reddy; C Rama Prasad; P Hemalatha Reddy; Dennis Reeder; Keith McKenney; Howard Jaffe; Mariana N Dimitrova; Ann Ginsburg; Alan Peterkofsky; P Suryanarayana Murthy
Journal:  J Bacteriol       Date:  2003-09       Impact factor: 3.490

8.  Activity of trifluoperazine against replicating, non-replicating and drug resistant M. tuberculosis.

Authors:  Meeta J Advani; Imran Siddiqui; Pawan Sharma; Hemalatha Reddy
Journal:  PLoS One       Date:  2012-08-31       Impact factor: 3.240
  8 in total

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