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Literature DB >> 14262788

THE USE OF SUBSTITUENT CONSTANTS IN THE ANALYSIS OF THE STRUCTURE--ACTIVITY RELATIONSHIP IN PENICILLIN DERIVATIVES.

Abstract

Entities: Chemical

Keywords: CHEMISTRY, PHARMACEUTICAL; EXPERIMENTAL LAB STUDY; MICE; PENICILLIN; PHARMACOLOGY; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS

Mesh：

Substances：
Penicillins

Year: 1964 PMID： 14262788 DOI： 10.1021/jm00336a001

Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446

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Cited

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13 in total

1. Comparison of commercially available genetic algorithms: gas as variable selection tool.

Authors: Sabine Schefzick; Mary Bradley
Journal: J Comput Aided Mol Des Date: 2004 Jul-Sep Impact factor: 3.686

Review 2. Computer-aided drug discovery and development (CADDD): in silico-chemico-biological approach.

Authors: I M Kapetanovic
Journal: Chem Biol Interact Date: 2006-12-16 Impact factor: 5.192

3. Neutralizing positive charges at the surface of a protein lowers its rate of amide hydrogen exchange without altering its structure or increasing its thermostability.

Authors: Bryan F Shaw; Haribabu Arthanari; Max Narovlyansky; Armando Durazo; Dominique P Frueh; Michael P Pollastri; Andrew Lee; Basar Bilgicer; Steven P Gygi; Gerhard Wagner; George M Whitesides
Journal: J Am Chem Soc Date: 2010-11-19 Impact factor: 15.419

THE USE OF SUBSTITUENT CONSTANTS IN THE ANALYSIS OF THE STRUCTURE--ACTIVITY RELATIONSHIP IN PENICILLIN DERIVATIVES.

1. Comparison of commercially available genetic algorithms: gas as variable selection tool.

Review 2. Computer-aided drug discovery and development (CADDD): in silico-chemico-biological approach.

3. Neutralizing positive charges at the surface of a protein lowers its rate of amide hydrogen exchange without altering its structure or increasing its thermostability.

Review 4. How medicinal chemists learned about log P.

5. Antiaggregatory activity of imidazoline drugs and chemicals as a function of their structure.

6. Relationship between R m values and protein binding of corticosteroids and androgens.

7. Binding of antibiotics to bovine and ovine serum.

8. Chromatography of penicillins, penicilloates, and penicilloylamides on dextran gels.

9. Lysine acetylation can generate highly charged enzymes with increased resistance toward irreversible inactivation.

10. Transport of steroid hormones through the rat blood-brain barrier. Primary role of albumin-bound hormone.