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Literature DB >> 1426236

Molecular cloning and developmental expression of a human kidney S-adenosylmethionine synthetase.

Abstract

cDNA clones encoding the human kidney S-adenosylmethionine synthetase (kidney-type isozyme) were isolated. The amino acid sequence deduced from the cDNA indicates that this enzyme contains 395 amino acids and has a molecular mass of 43,660 Da. The predicted amino acid sequence of this protein shares 84% similarity with that of human liver S-adenosylmethionine synthetase (liver-type isozyme). In addition, the developmental expression of these two isozyme mRNAs has been studied in the human liver using the reverse transcription-polymerase chain reaction (RT-PCR).

Entities: Gene Species

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Year: 1992 PMID： 1426236 DOI： 10.1016/0014-5793(92)81405-b

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

29 in total

1. Proteomic analysis of human hepatoma cells expressing methionine adenosyltransferase I/III: Characterization of DDX3X as a target of S-adenosylmethionine.

Authors: Paul C Schröder; Joaquín Fernández-Irigoyen; Emilie Bigaud; Antonio Serna; Rubén Renández-Alcoceba; Shelly C Lu; José M Mato; Jesús Prieto; Fernando J Corrales
Journal: J Proteomics Date: 2012-01-16 Impact factor: 4.044

2. Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation.

Authors: S C Lu; L Alvarez; Z Z Huang; L Chen; W An; F J Corrales; M A Avila; G Kanel; J M Mato
Journal: Proc Natl Acad Sci U S A Date: 2001-04-24 Impact factor: 11.205

3. S-Adenosylmethionine and methylthioadenosine inhibit cellular FLICE inhibitory protein expression and induce apoptosis in colon cancer cells.

Authors: Tony W H Li; Qingsong Zhang; Pilsoo Oh; Meng Xia; Hui Chen; Sean Bemanian; Natalie Lastra; Magda Circ; Mary Pat Moyer; José M Mato; Tak Yee Aw; Shelly C Lu
Journal: Mol Pharmacol Date: 2009-04-16 Impact factor: 4.436

4. Demyelination of the brain is associated with methionine adenosyltransferase I/III deficiency.

Authors: M E Chamberlin; T Ubagai; S H Mudd; W G Wilson; J V Leonard; J Y Chou
Journal: J Clin Invest Date: 1996-08-15 Impact factor: 14.808

5. Dominant inheritance of isolated hypermethioninemia is associated with a mutation in the human methionine adenosyltransferase 1A gene.

Authors: M E Chamberlin; T Ubagai; S H Mudd; H L Levy; J Y Chou
Journal: Am J Hum Genet Date: 1997-03 Impact factor: 11.025

Molecular cloning and developmental expression of a human kidney S-adenosylmethionine synthetase.

1. Proteomic analysis of human hepatoma cells expressing methionine adenosyltransferase I/III: Characterization of DDX3X as a target of S-adenosylmethionine.

2. Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation.

3. S-Adenosylmethionine and methylthioadenosine inhibit cellular FLICE inhibitory protein expression and induce apoptosis in colon cancer cells.

4. Demyelination of the brain is associated with methionine adenosyltransferase I/III deficiency.

5. Dominant inheritance of isolated hypermethioninemia is associated with a mutation in the human methionine adenosyltransferase 1A gene.

6. Inhibition of human methionine adenosyltransferase 1A transcription by coding region methylation.

7. Interleukin-2 induces gamma-S-adenosyl-L-methionine synthetase gene expression during T-lymphocyte activation.

8. Hormonal regulation of S-adenosylmethionine synthase transcripts in pea ovaries.

Review 9. S-adenosylmethionine in liver health, injury, and cancer.

Review 10. The role of genetics in the establishment and maintenance of the epigenome.