Literature DB >> 1426148

Mechanoelectrical transduction, ion movement and water stasis in uromodulin.

M Mattey1, L Naftalin.   

Abstract

Mechanical movement of a column of the urinary glycoprotein uromodulin modulates an applied voltage. This change is a property of the glycoprotein and its interaction with the walls of the container and is related to its capacitance. The voltage modulation is not accompanied by changes in rotationally restricted water as has been reported for hyaluronic acid. Diffusion experiments with tritiated water also support the hypothesis that uromodulin acts as a water barrier, but allows ion movement.

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Year:  1992        PMID： 1426148     DOI： 10.1007/bf01919145

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  16 in total

1.  Hyaluronic acid salt--a mechanoelectrical transducer.

Authors:  T W Barrett
Journal:  Biochim Biophys Acta       Date:  1975-03-14

2.  ON HYALURONATE MOLECULES IN THE LABYRINTH AS MECHANOELECTRICAL TRANSDUCERS, AND AS MOLECULAR MOTORS ACTING AS RESONATORS.

Authors:  J A CHRISTIANSEN
Journal:  Acta Otolaryngol       Date:  1964 Jan-Feb       Impact factor: 1.494

3.  Role of hyaluronidase in the re-absorption of water in renal tubules: the mechanism of action of the antidiuretic hormone.

Authors:  A G GINETZINSKY
Journal:  Nature       Date:  1958-11-01       Impact factor: 49.962

4.  Tamm-Horsfall mucoprotein. I. Localization in the kidney.

Authors:  E A Schenk; R H Schwartz; R A Lewis
Journal:  Lab Invest       Date:  1971-07       Impact factor: 5.662

5.  Function of the thick ascending limb of Henle's loop.

Authors:  M B Burg; N Green
Journal:  Am J Physiol       Date:  1973-03

6.  The chemical composition and electron microscopic appearance of a protein derived from urinary casts.

Authors:  A P Fletcher; J E McLaughlin; W A Ratcliffe; D A Woods
Journal:  Biochim Biophys Acta       Date:  1970-08-21

7.  Some factors affecting the production, by cultured baby-hamster kidney cells, of BHK glycoprotein I which cross-reacts immunologically with Tamm-Horsfall glycoprotein.

Authors:  F J Bloomfield; D R Dunstan; C L Foster; F Serafini-Cessi; R D Marshall
Journal:  Biochem J       Date:  1977-04-15       Impact factor: 3.857

8.  Sodium chloride and water transport in the medullary thick ascending limb of Henle. Evidence for active chloride transport.

Authors:  A S Rocha; J P Kokko
Journal:  J Clin Invest       Date:  1973-03       Impact factor: 14.808

9.  Dielectric behavior of water in biological solutions: studies on myoglobin, human low-density lipoprotein, and polyvinylpyrrolidone.

Authors:  E H Grant; V E McClean; N R Nightingale; R J Sheppard; M J Chapman
Journal:  Bioelectromagnetics       Date:  1986       Impact factor: 2.010

10.  A mucoprotein derived from human urine which reacts with influenza, mumps, and Newcastle disease viruses.

Authors:  I TAMM; F L HORSFALL
Journal:  J Exp Med       Date:  1952-01       Impact factor: 14.307
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  9 in total

1.  Uromodulin is expressed in renal primary cilia and UMOD mutations result in decreased ciliary uromodulin expression.

Authors:  Frank Zaucke; Joana M Boehnlein; Sarah Steffens; Roman S Polishchuk; Luca Rampoldi; Andreas Fischer; Andreas Pasch; Christoph W A Boehm; Anne Baasner; Massimo Attanasio; Bernd Hoppe; Helmut Hopfer; Bodo B Beck; John A Sayer; Friedhelm Hildebrandt; Matthias T F Wolf
Journal:  Hum Mol Genet       Date:  2010-02-18       Impact factor: 6.150

2.  Selectively reduced expression of thick ascending limb Tamm-Horsfall protein in hypothyroid kidneys.

Authors:  Roland Schmitt; Thomas Kahl; Kerim Mutig; Sebastian Bachmann
Journal:  Histochem Cell Biol       Date:  2004-03-09       Impact factor: 4.304

3.  Analysis of uromodulin polymerization provides new insights into the mechanisms regulating ZP domain-mediated protein assembly.

Authors:  Céline Schaeffer; Sara Santambrogio; Simone Perucca; Giorgio Casari; Luca Rampoldi
Journal:  Mol Biol Cell       Date:  2008-11-12       Impact factor: 4.138

4.  Tamm-Horsfall glycoprotein in streptozotocin diabetic rats: a study of kidney in situ hybridization, immunohistochemistry, and urinary excretion.

Authors:  R Rasch; O Torffvit; S Bachmann; P K Jensen; N O Jacobsen
Journal:  Diabetologia       Date:  1995-05       Impact factor: 10.122

5.  A mouse model for inherited renal fibrosis associated with endoplasmic reticulum stress.

Authors:  Sian E Piret; Eric Olinger; Anita A C Reed; M Andrew Nesbit; Tertius A Hough; Liz Bentley; Olivier Devuyst; Roger D Cox; Rajesh V Thakker
Journal:  Dis Model Mech       Date:  2017-03-21       Impact factor: 5.758

6.  Polymerization-Incompetent Uromodulin in the Pregnant Stroke-Prone Spontaneously Hypertensive Rat.

Authors:  Sheon Mary; Heather Yvonne Small; Justyna Siwy; William Mullen; Ashok Giri; Christian Delles
Journal:  Hypertension       Date:  2017-03-27       Impact factor: 10.190

7.  Histological and MS spectrometric analyses of the modified tissue of bulgy form tadpoles induced by salamander predation.

Authors:  Tsukasa Mori; Yoichiro Kitani; Jun Ogihara; Manabu Sugiyama; Goshi Yamamoto; Osamu Kishida; Kinya Nishimura
Journal:  Biol Open       Date:  2012-02-08       Impact factor: 2.422

8.  Identification of a novel uromodulin-like gene related to predator-induced bulgy morph in anuran tadpoles by functional microarray analysis.

Authors:  Tsukasa Mori; Hiroko Kawachi; Chiharu Imai; Manabu Sugiyama; Youichi Kurata; Osamu Kishida; Kinya Nishimura
Journal:  PLoS One       Date:  2009-06-16       Impact factor: 3.240

9.  A GPI-anchored sea urchin sperm membrane protein containing EGF domains is related to human uromodulin.

Authors:  L M Mendoza; D Nishioka; V D Vacquier
Journal:  J Cell Biol       Date:  1993-06       Impact factor: 10.539
  9 in total

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