Literature DB >> 1426093

The role of glutathione in aging and cancer.

J P Richie1.   

Abstract

The incidence and mortality rates from most cancers increase exponentially with age. It is likely that this aging phenomenon is partially due to specific changes that occur in the host resulting in an increased susceptibility to neoplasia. Our hypothesis is that one such host factor is a deficiency in GSH, based on the importance of this compound in the detoxification of a wide variety of exogenous and endogenous carcinogens and free radicals, as well as in the maintenance of immune function.

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Year:  1992        PMID： 1426093     DOI： 10.1016/0531-5565(92)90015-r

Source DB:  PubMed          Journal:  Exp Gerontol        ISSN： 0531-5565            Impact factor:   4.032


  12 in total

1.  Age related changes in selenium and glutathione levels in different lobes of the rat prostate.

Authors:  John P Richie; Arunangshu Das; Ana M Calcagnotto; Cesar A Aliaga; Karam El-Bayoumy
Journal:  Exp Gerontol       Date:  2011-12-24       Impact factor: 4.032

2.  The cystine/glutamate antiporter regulates dendritic cell differentiation and antigen presentation.

Authors:  June A D'Angelo; Eleonora Dehlink; Barbara Platzer; Peter Dwyer; Magdalena L Circu; Jone Garay; Tak Yee Aw; Edda Fiebiger; Bonny L Dickinson
Journal:  J Immunol       Date:  2010-08-23       Impact factor: 5.422

3.  Antioxidative mechanisms and plasma growth hormone levels: potential relationship in the aging process.

Authors:  H M Brown-Borg; A M Bode; A Bartke
Journal:  Endocrine       Date:  1999-08       Impact factor: 3.633

4.  Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns.

Authors:  J D Peterson; L A Herzenberg; K Vasquez; C Waltenbaugh
Journal:  Proc Natl Acad Sci U S A       Date:  1998-03-17       Impact factor: 11.205

5.  The effect of prostate cancer and antiandrogenic therapy on lipid peroxidation and antioxidant systems.

Authors:  Alkan Hacer Iynem; Ayşe Zeynep Alademir; Can Obek; Ali Riza Kural; Dildar Konukoğlu; Tülay Akçay
Journal:  Int Urol Nephrol       Date:  2004       Impact factor: 2.370

6.  The cystine/glutamate antiporter regulates indoleamine 2,3-dioxygenase protein levels and enzymatic activity in human dendritic cells.

Authors:  Mildred L Mattox; June A D'Angelo; Zachary M Grimes; Edda Fiebiger; Bonny L Dickinson
Journal:  Am J Clin Exp Immunol       Date:  2012-11-30

7.  Long-term garlic or micronutrient supplementation, but not anti-Helicobacter pylori therapy, increases serum folate or glutathione without affecting serum vitamin B-12 or homocysteine in a rural Chinese population.

Authors:  Yujue Wang; Lian Zhang; Roxana Moslehi; Junling Ma; Kaifeng Pan; Tong Zhou; Weidong Liu; Linda Morris Brown; Yuangreng Hu; David Pee; Mitchell H Gail; Weicheng You
Journal:  J Nutr       Date:  2008-12-03       Impact factor: 4.798

8.  Blood glutathione levels in head and neck malignancies.

Authors:  Y P Singh; O P Sachdeva; S K Aggarwal; K Chugh; Harbans Lal
Journal:  Indian J Clin Biochem       Date:  2008-10-01

9.  Glutathione depletion and recovery after acute ethanol administration in the aging mouse.

Authors:  Barbara L Vogt; John P Richie
Journal:  Biochem Pharmacol       Date:  2007-01-30       Impact factor: 5.858

10.  Encorafenib enhances TRAIL-induced apoptosis of colorectal cancer cells dependent on p53/PUMA signaling.

Authors:  Zhenqing Sun; Zhigang Qiu; Bin Ma; Zhengkun Wang
Journal:  Cytotechnology       Date:  2020-11-13       Impact factor: 2.058
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