Literature DB >> 14260867

THE METABOLIC FORMATION OF GAMMA-(3-PYRIDYL)-GAMMA-HYDROXYBUTYRIC ACID AND ITS POSSIBLE INTERMEDIARY ROLE IN THE MAMMALIAN METABOLISM OF NICOTINE.

H MCKENNIS, S L SCHWARTZ, L B TURNBULL, E TAMAKI, E R BOWMAN.   

Abstract

Entities:  

Keywords:  CHROMATOGRAPHY; DOGS; EXPERIMENTAL LAB STUDY; HYDROXYBUTYRATES; METABOLISM; NICOTINE; PYRIDINES; RABBITS; RATS; SPECTROPHOTOMETRY; URINE

Mesh：

Substances：

Year:  1964        PMID： 14260867

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


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  6 in total

1.  2'-Hydroxylation of nicotine by cytochrome P450 2A6 and human liver microsomes: formation of a lung carcinogen precursor.

Authors:  S S Hecht; J B Hochalter; P W Villalta; S E Murphy
Journal:  Proc Natl Acad Sci U S A       Date:  2000-11-07       Impact factor: 11.205

2.  The in vitro metabolism of norcotinine and related biotransformation products by microsomal preparations.

Authors:  N Eldirdiri; M Ulgen; P Jacob; J W Gorrod
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1997 Oct-Dec       Impact factor: 2.441

3.  Formation and distribution of NNK metabolites in an isolated perfused rat lung.

Authors:  Laura A Maertens; Pramod Upadhyaya; Stephen S Hecht; Cheryl L Zimmerman
Journal:  Drug Metab Dispos       Date:  2010-02-16       Impact factor: 3.922

4.  Extensive metabolic activation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in smokers.

Authors:  Irina Stepanov; Pramod Upadhyaya; Steven G Carmella; Rachel Feuer; Joni Jensen; Dorothy K Hatsukami; Stephen S Hecht
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2008-07       Impact factor: 4.254

5.  The tobacco carcinogen NNK is stereoselectively reduced by human pancreatic microsomes and cytosols.

Authors:  Neil Trushin; Gerhard Leder; Karam El-Bayoumy; Dietrich Hoffmann; Hans G Beger; Doris Henne-Bruns; Marco Ramadani; Bogdan Prokopczyk
Journal:  Langenbecks Arch Surg       Date:  2008-02-08       Impact factor: 3.445

6.  Liquid chromatography-electrospray ionization-tandem mass spectrometry quantitation of urinary [pyridine-D4]4-hydroxy-4-(3-pyridyl)butanoic acid, a biomarker of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolic activation in smokers.

Authors:  Meng Jing; Yaohua Wang; Pramod Upadhyaya; Vipin Jain; Jian-Min Yuan; Dorothy K Hatsukami; Stephen S Hecht; Irina Stepanov
Journal:  Chem Res Toxicol       Date:  2014-08-25       Impact factor: 3.739
  6 in total

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