Literature DB >> 1426019

Marked decrease of A10 dopamine neuronal firing during ethanol withdrawal syndrome in rats.

M Diana1, M Pistis, A Muntoni, Z L Rossetti, G Gessa.   

Abstract

The electrophysiological activity of mesoaccumbens dopaminergic neurons was monitored during the ethanol-withdrawal syndrome in ethanol-dependent and in control rats. Spontaneous firing was reduced by about half in ethanol-dependent rats as compared to controls. Likewise, the number of spikes/burst was also reduced in ethanol-dependent rats. These results are consistent with the reduction in dopamine release observed during ethanol-withdrawal syndrome and may provide the basis for the aversive effects of the ethanol-withdrawal syndrome.

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Year:  1992        PMID： 1426019     DOI： 10.1016/0014-2999(92)90734-l

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  16 in total

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5.  Profound decrement of mesolimbic dopaminergic neuronal activity during ethanol withdrawal syndrome in rats: electrophysiological and biochemical evidence.

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