Literature DB >> 14259767

CEREBELLAR DISEASE IN CATS INDUCED BY INOCULATION OF RAT VIRUS.

L KILHAM, G MARGOLIS.   

Abstract

Rat virus selectively destroys the external germinal layer of the cerebellar cortex when inoculated intracerebrally into newborn cats. The lesions are marked by numerous intranuclear inclusion bodies and a rise of virus titers. These effects suggest that the spontaneous ataxia of cats which is accompanied by cerebellar hypoplasia, may be of viral origin.

Entities:  

Keywords:  ANIMALS, NEWBORN; ANTIBODY FORMATION; ATAXIA; CATS; CEREBELLAR DISEASES; EXPERIMENTAL LAB STUDY; HEMAGGLUTINATION; INJECTIONS, INTRATHECAL; PATHOLOGY; RATS; VIRUS DISEASES

Mesh:

Year:  1965        PMID: 14259767     DOI: 10.1126/science.148.3667.244

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  5 in total

1.  The induction of hepatitis by prior partial hepatectomy in resistant adult rats injected with H-1 virus. Light and electron microscopy and virologic studies.

Authors:  P R Ruffolo; G Margolis; L Kilham
Journal:  Am J Pathol       Date:  1966-11       Impact factor: 4.307

2.  Parvovirus minute virus of mice strain i multiplication and pathogenesis in the newborn mouse brain are restricted to proliferative areas and to migratory cerebellar young neurons.

Authors:  J C Ramírez; A Fairén; J M Almendral
Journal:  J Virol       Date:  1996-11       Impact factor: 5.103

3.  Viral etiology of spontaneous ataxia of cats.

Authors:  L Kilham; G Margolis
Journal:  Am J Pathol       Date:  1966-06       Impact factor: 4.307

4.  Spontaneous hepatitis and cerebellar "hypoplasia" in suckling rats due to congenital infections with rat virus.

Authors:  L Kilham; G Margolis
Journal:  Am J Pathol       Date:  1966-09       Impact factor: 4.307

Review 5.  Potential detrimental effects of rodent viral infections on long-term experiments.

Authors:  G Lussier
Journal:  Vet Res Commun       Date:  1988       Impact factor: 2.459

  5 in total

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