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Literature DB >> 14259766

HISTONE REGULATION OF LACTIC DEHYDROGENASE IN EMBRYONIC CHICK BRAIN TISSUE.

Abstract

Histone, when added at low concentrations to cultures of embryonic chick brain tissue, causes an inductive response in lactic dehydrogenase activity, whereas at higher concentrations of histone the response is repressive. This control is shown to operate by altering protein synthesis. Thus, histones exercise a primary regulatory function in the chick. Unlike lactic dehydrogenase, acetylcholine esterase is stable in this system and is not affected by histones or inhibitors of protein synthesis.

Entities: Disease Species

Keywords: ACETYLCHOLINESTERASE; ACTINOMYCIN; AMINO ACIDS; BRAIN ENZYMOLOGY; CHEMISTRY; CHICK EMBRYO; DNA; EMBRYO; EXPERIMENTAL LAB STUDY; HISTONES; LACTATE DEHYDROGENASE; PHARMACOLOGY; PROTEIN METABOLISM; PUROMYCIN; TISSUE CULTURE

Mesh：

Substances：

Year: 1965 PMID： 14259766 DOI： 10.1126/science.148.3667.242

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

11 in total

1. Interrelationships between ganglionic acetylcholinesterase and nonspecific cholinesterase of the cat and rat.

Authors: G B Koelle; K K Rickard; G A Ruch
Journal: Proc Natl Acad Sci U S A Date: 1979-11 Impact factor: 11.205

2. Histone-induced changes of protein synthesis in Escherichia coli. II. Effect of histone on alkaline phosphatase synthesis.

Authors: E Masnerová; S Strbánová-Necinová
Journal: Folia Microbiol (Praha) Date: 1973 Impact factor: 2.099

3. Histone-induced changes of protein synthesis in Escherichia coli.

Authors: S Strbánová-Necinová; E Stejskalová; E Pavlasová
Journal: Folia Microbiol (Praha) Date: 1972 Impact factor: 2.099

4. Effects of pH, ionic strength, and metabolic intermediates on the rates of heat inactivation of lactate dehydrogenase isozymes.

Authors: E S Vesell; K L Yielding
Journal: Proc Natl Acad Sci U S A Date: 1966-10 Impact factor: 11.205

HISTONE REGULATION OF LACTIC DEHYDROGENASE IN EMBRYONIC CHICK BRAIN TISSUE.

1. Interrelationships between ganglionic acetylcholinesterase and nonspecific cholinesterase of the cat and rat.

2. Histone-induced changes of protein synthesis in Escherichia coli. II. Effect of histone on alkaline phosphatase synthesis.

3. Histone-induced changes of protein synthesis in Escherichia coli.

4. Effects of pH, ionic strength, and metabolic intermediates on the rates of heat inactivation of lactate dehydrogenase isozymes.

5. Morphological changes in Escherichia coli and Bacillus cereus caused by external histone.

6. Effects of histones on embryonic cells.

7. Regulation of Nitrate Reductase Activity in Corn (Zea mays L.) Seedlings by Endogenous Metabolites.

8. Stimulation of liver cholesterol synthesis by actinomycin D.

9. Hybridizable ribonucleic acid of rat brain.

10. Enhanced malignant behaviour of cells treated with crude rat liver histone.