Literature DB >> 1425959

Effect of LY 83583 on relaxation induced by non-adrenergic non-cholinergic nerve stimulation and exogenous nitric oxide in the rat gastric fundus.

A J Barbier1, R A Lefebvre.   

Abstract

In the rat gastric fundus, the reported cGMP-lowering agent LY 83583 (10(-5) M) inhibited the relaxation induced by nitric oxide (NO), without altering the response to isoprenaline, vasoactive intestinal polypeptide, sodium nitroprusside or electrical field stimulation of inhibitory non-adrenergic non-cholinergic neurones, which are thought to release NO. Incubation with superoxide dismutase partially prevented the effect of LY 83583. When added during a relaxation maintained by continuous NO infusion, LY 83583 reversed the relaxation. It is concluded that LY 83583 inactivates exogenous NO through the generation of superoxide anions.

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Year:  1992        PMID： 1425959     DOI： 10.1016/0014-2999(92)90315-u

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  19 in total

Review 1.  NO as a signalling molecule in the nervous system.

Authors:  Juan V Esplugues
Journal:  Br J Pharmacol       Date:  2002-03       Impact factor: 8.739

2.  Effect of Cu2+ on relaxations to the nitrergic neurotransmitter, NO and S-nitrosothiols in the rat gastric fundus.

Authors:  J G De Man; B Y De Winter; G E Boeckxstaens; A G Herman; P A Pelckmans
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3.  Effect of thiol modulators and Cu/Zn superoxide dismutase inhibition on nitrergic relaxations in the rat gastric fundus.

Authors:  J G De Man; B Y De Winter; G E Boeckxstaens; A G Herman; P A Pelckmans
Journal:  Br J Pharmacol       Date:  1996-11       Impact factor: 8.739

4.  Interaction of hypoxanthine/xanthine oxidase with nitrergic relaxation in the porcine gastric fundus.

Authors:  E E Colpaert; R A Lefebvre
Journal:  Br J Pharmacol       Date:  2000-05       Impact factor: 8.739

5.  In vivo microdialysis study of a specific inhibitor of soluble guanylyl cyclase on the glutamate receptor/nitric oxide/cyclic GMP pathway.

Authors:  E Fedele; Y Jin; G Varnier; M Raiteri
Journal:  Br J Pharmacol       Date:  1996-10       Impact factor: 8.739

6.  Tonic inhibitory action by nitric oxide on spontaneous mechanical activity in rat proximal colon: involvement of cyclic GMP and apamin-sensitive K+ channels.

Authors:  F Mulè; S D'Angelo; R Serio
Journal:  Br J Pharmacol       Date:  1999-05       Impact factor: 8.739

7.  Effects of pyrogallol, hydroquinone and duroquinone on responses to nitrergic nerve stimulation and NO in the rat anococcygeus muscle.

Authors:  M La; M J Rand
Journal:  Br J Pharmacol       Date:  1999-01       Impact factor: 8.739

8.  Influence of S-nitrosothiols and nitrate tolerance in the rat gastric fundus.

Authors:  A J Barbier; R A Lefebvre
Journal:  Br J Pharmacol       Date:  1994-04       Impact factor: 8.739

9.  Nitric oxide synthase activity and non-adrenergic non-cholinergic relaxation in the rat gastric fundus.

Authors:  D Currò; A R Volpe; P Preziosi
Journal:  Br J Pharmacol       Date:  1996-02       Impact factor: 8.739

10.  Discrimination by the NO-trapping agent, carboxy-PTIO, between NO and the nitrergic transmitter but not between NO and EDRF.

Authors:  M J Rand; C G Li
Journal:  Br J Pharmacol       Date:  1995-09       Impact factor: 8.739
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