Literature DB >> 1425939

Blockade of hyperalgesia and neurogenic oedema by topical application of nitroglycerin.

S H Ferreira1, B B Lorenzetti, L H Faccioli.   

Abstract

Surprisingly, a single topical application of a nitroglycerin (NTG) gel in humans has been shown to cause analgesia and to reduce oedema in thrombophlebitis. In the present investigation, we showed that the NTG gel reduces prostaglandin E2-induced hyperalgesia and blocks neurogenic inflammation induced in rat skin by antidromic electrical stimulation of the saphenous nerve. These results offer an explanation for the effects of topical application of NTG observed in thrombophlebitis, which may be common to other cutaneous pathologies. The data also support the development of nitrates the effects of which are restricted to the site of application.

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Year:  1992        PMID： 1425939     DOI： 10.1016/0014-2999(92)90871-z

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  14 in total

1.  Role of the haeme oxygenase/carbon monoxide pathway in mechanical nociceptor hypersensitivity.

Authors:  A A Steiner; L G Branco; F Q Cunha; S H Ferreira
Journal:  Br J Pharmacol       Date:  2001-04       Impact factor: 8.739

2.  Pharmacological modulation of secondary mediator systems--cyclic AMP and cyclic GMP--on inflammatory hyperalgesia.

Authors:  F Q Cunha; M M Teixeira; S H Ferreira
Journal:  Br J Pharmacol       Date:  1999-06       Impact factor: 8.739

3.  Reduction of pain on injection of propofol: combination of nitroglycerin and lidocaine.

Authors:  Younghoon Jeon
Journal:  J Anesth       Date:  2012-04-24       Impact factor: 2.078

Review 4.  Mechanisms of action of nitrates.

Authors:  K E Torfgård; J Ahlner
Journal:  Cardiovasc Drugs Ther       Date:  1994-10       Impact factor: 3.727

5.  Superoxide and Nitric Oxide Involvement in Enhancing of N-methyl-D-aspartate Receptor-Mediated Central Sensitization in the Chronic Post-ischemia Pain Model.

Authors:  Tae Ha Ryu; Kyung Young Jung; Mi Jin Ha; Kyung Hwa Kwak; Dong Gun Lim; Jung Gil Hong
Journal:  Korean J Pain       Date:  2010-03-10

6.  Does the use of ketamine or nitroglycerin as an adjuvant to lidocaine improve the quality of intravenous regional anesthesia?

Authors:  Khaled Fawzy Elmetwaly; Nasr Abdelmohsen Hegazy; Abdelkhalek Abdelmonem Aboelseoud; Ahmad Abdullah Alshaer
Journal:  Saudi J Anaesth       Date:  2010-05

7.  Transdermal nitroglycerin as an adjuvant to patient-controlled morphine analgesia after total knee arthroplasty.

Authors:  Sharon Orbach-Zinger; Artium Lenchinsky; Lesley Paul-Kesslin; Steven Velks; Moses Salai; Leonid A Eidelman
Journal:  Pain Res Manag       Date:  2009 Mar-Apr       Impact factor: 3.037

8.  L-arginine exerts a dual role in nociceptive processing in the brain: involvement of the kyotorphin-Met-enkephalin pathway and NO-cyclic GMP pathway.

Authors:  A Kawabata; N Umeda; H Takagi
Journal:  Br J Pharmacol       Date:  1993-05       Impact factor: 8.739

9.  Antagonism of the antinociceptive effect of nitrous oxide by inhibition of enzyme activity or expression of neuronal nitric oxide synthase in the mouse brain and spinal cord.

Authors:  Jessica Lack Cope; Eunhee Chung; Yusuke Ohgami; Raymond M Quock
Journal:  Eur J Pharmacol       Date:  2009-10-08       Impact factor: 4.432

10.  Effect of topical administration of L-arginine on formalin-induced nociception in the mouse: a dual role of peripherally formed NO in pain modulation.

Authors:  A Kawabata; S Manabe; Y Manabe; H Takagi
Journal:  Br J Pharmacol       Date:  1994-06       Impact factor: 8.739
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