Literature DB >> 1425900

Comparative bioavailability of two different rectal preparations of piroxicam in man.

S Benkö1, G Grézal, E Nagy, I Klebovich.   

Abstract

A comparative pharmacokinetic study was performed with two types of suppository each containing 20 mg piroxicam. The bioavailability of piroxicam was studied in 24 healthy volunteers in a double blind, randomised, cross over study. No significant difference was found in the pharmacokinetic parameters [AUC(0-72 h), AUC, Cmax, t1/2 beta] calculated from plasma concentration time curves, indicating that the two preparations were bioequivalent.

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Year:  1992        PMID: 1425900     DOI: 10.1007/bf02333031

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN: 0031-6970            Impact factor:   2.953


  18 in total

1.  Acidic antiinflammatory agents--correlations of some physical, pharmacological and clinical data.

Authors:  J G Lombardino; I G Otterness; E H Wiseman
Journal:  Arzneimittelforschung       Date:  1975-10

2.  Symmetrical confidence intervals for bioequivalence trials.

Authors:  W J Westlake
Journal:  Biometrics       Date:  1976-12       Impact factor: 2.571

3.  A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability.

Authors:  D J Schuirmann
Journal:  J Pharmacokinet Biopharm       Date:  1987-12

4.  Some pharmacokinetic properties and bioavailability by oral and rectal route of piroxicam in rodents and in man.

Authors:  P Schiantarelli; D Acerbi; G Bovis
Journal:  Arzneimittelforschung       Date:  1981

5.  [Pharmacokinetic study of piroxicam following oral and rectal administration].

Authors:  D Acerbi; L Daccò; E Palummeri
Journal:  Boll Chim Farm       Date:  1983-09

6.  Analysis of piroxicam in plasma by high-performance liquid chromatography.

Authors:  T M Twomey; S R Bartolucci; D C Hobbs
Journal:  J Chromatogr       Date:  1980-07-11

7.  Piroxicam, a novel anti-inflammatory agent.

Authors:  E H Wiseman; Y H Chang; J G Lombardino
Journal:  Arzneimittelforschung       Date:  1976

8.  Potent anti-inflammatory N-heterocyclic 3-carboxamides of 4-hydroxy-2-methyl-2H-1,2-benzothiazine 1,1-dioxide.

Authors:  J G Lombardino; E H Wiseman; J Chiaini
Journal:  J Med Chem       Date:  1973-05       Impact factor: 7.446

9.  Kinetics of single doses of fenbufen in patients with renal insufficiency.

Authors:  H J Rogers; J P Savitsky; B Glenn; R G Spector
Journal:  Clin Pharmacol Ther       Date:  1981-01       Impact factor: 6.875

Review 10.  Piroxicam: a review of its pharmacological properties and therapeutic efficacy.

Authors:  R N Brogden; R C Heel; T M Speight; G S Avery
Journal:  Drugs       Date:  1981-09       Impact factor: 9.546

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