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Literature DB >> 1425892

Dose-dependent absorption of amoxicillin in patients with an ileostomy.

J Sjövall¹, G Alván, J E Akerlund, J O Svensson, G Paintaud, C E Nord, B Angelin.

Abstract

Amoxicillin was given as single doses of 375, 700, 1500, 3000 and 6000 mg an oral suspension to four volunteers with an ileostomy and with no active intestinal disease after an overnight fast. The excretion of amoxicillin and its penicilloic acid was followed in samples taken from the ileostomy and in urine produced over 6 h. Beta-lactamase activity was measured in ileal fluid and none was found. The percentage of the dose recovered from the ileostomy increased successively from 8% at the lowest dose to 77% at the highest dose. A complementary excretion pattern of amoxicillin was found in the urine, amounting to 70% recovery at the lowest dose to 23% at the highest dose. The results confirm the dose-dependence of the absorption of amoxicillin, which could at least in part be due to specialised absorption of this drug in humans.

Entities: Chemical Disease Species

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Year: 1992 PMID： 1425892 DOI： 10.1007/bf02333023

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

18 in total

1. Effect of clavulanic acid on inactivated amoxicillin excretion in urinary tract infection.

Authors: K Miyazaki; K Iseki; T Ishizawa; T Arita; S Sakai; Y Kumamoto
Journal: Clin Pharmacol Ther Date: 1985-05 Impact factor: 6.875

2. Saturable rate of cefatrizine absorption after oral administration to humans.

Authors: B G Reigner; W Couet; J P Guedes; J B Fourtillan; T N Tozer
Journal: J Pharmacokinet Biopharm Date: 1990-02

3. Physicochemical properties of amphoteric beta-lactam antibiotics I: Stability, solubility, and dissolution behavior of amino penicillins as a function of pH.

Authors: A Tsuji; E Nakashima; S Hamano; T Yamana
Journal: J Pharm Sci Date: 1978-08 Impact factor: 3.534

4. Intestinal absorption mechanism of amino-beta-lactam antibiotics. III. Kinetics of carrier-mediated transport across the rat small intestine in situ.

Authors: E Nakashima; A Tsuji; S Kagatani; T Yamana
Journal: J Pharmacobiodyn Date: 1984-07

Dose-dependent absorption of amoxicillin in patients with an ileostomy.

1. Effect of clavulanic acid on inactivated amoxicillin excretion in urinary tract infection.

2. Saturable rate of cefatrizine absorption after oral administration to humans.

3. Physicochemical properties of amphoteric beta-lactam antibiotics I: Stability, solubility, and dissolution behavior of amino penicillins as a function of pH.

4. Intestinal absorption mechanism of amino-beta-lactam antibiotics. III. Kinetics of carrier-mediated transport across the rat small intestine in situ.

5. Oral cyclacillin interacts with the absorption of oral ampicillin, amoxycillin, and bacampicillin.

6. Predicting fraction dose absorbed in humans using a macroscopic mass balance approach.

7. Pharmacokinetics of amoxicillin: dose dependence after intravenous, oral, and intramuscular administration.

8. Comparative clinical pharmacology of bacampicillin and high oral doses of ampicillin.

9. Nonlinearity of amoxicillin absorption kinetics in human.

10. Stereospecific absorption and degradation of cephalexin.

1. Dose proportional absorption of 25-150 mg atenolol.

2. Limitations of the maximum entropy principle in devising drug input rate.

3. Pharmacokinetics of a new oral formulation of amoxicillin.

4. Lack of effect of amoxycillin on the absorption of ofloxacin.

5. Nonlinearity of amoxicillin absorption kinetics in human.

6. Modeling of the saturable time-constrained amoxicillin absorption in humans.