Literature DB >> 14258724

INDOLE COMPOUNDS: ISOLATION FROM PINEAL TISSUE.

W M MCISAAC, G FARRELL, R G TABORSKY, A N TAYLOR.   

Abstract

Five indole compounds have been isolated from bovine pineal tissue and characterized as 5-methoxytryptophol, N-acetyl-5-methoxytryptamine (melatonin), 5-hydroxytryptophol, 5-methoxyindole-3-acetic acid, and 5-hydroxyindole-3-acetic acid. Pineal hydroxyindole-O-methyltransferase, with S-adenosylmethionine, converts 5-hydroxytryptophol to 5-methoxytryptophol.

Entities:  

Keywords:  CATTLE; CHEMISTRY; CHROMATOGRAPHY; ELECTROPHORESIS; EXPERIMENTAL LAB STUDY; INDOLEACETIC ACID; INDOLES; PINEAL BODY; SPECTRUM ANALYSIS; TRANSFERASES; TRITIUM

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Year:  1965        PMID： 14258724     DOI： 10.1126/science.148.3666.102

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  10 in total

1.  The formation of 5-hydroxytryptophol in brain in vitro.

Authors:  D Eccleston; A T Moir; H W Reading; I M Ritchie
Journal:  Br J Pharmacol Chemother       Date:  1966-12

2.  Age-dependent effects of 5-methoxytryptophol and melatonin on testes and comb growth of the white leghorn (Gallus domesticus L.).

Authors:  M G Balemans
Journal:  J Neural Transm       Date:  1972       Impact factor: 3.575

3.  Fluorescence of indole derivatives.

Authors:  M G Balemans; F C van de Veerdonk
Journal:  Experientia       Date:  1967-11-15

4.  Separation of pineal extracts by gelfiltration. IV. Isolation, location and identification from sheep pineals of three indoles, identical with 5-hydroxytryptophol, 5-methoxytryptophol and melatonin.

Authors:  I Ebels; A E Horwitz-Bresser
Journal:  J Neural Transm       Date:  1976       Impact factor: 3.575

5.  Acyltryptophols reversibly inhibit muscle contractions caused by the actions of acetylcholine and raised potassium ion concentrations.

Authors:  I N Fernando; P L Francis; I Smith
Journal:  J Neural Transm       Date:  1983       Impact factor: 3.575

6.  Rapid distribution of tryptophol (3-indole ethanol) to the brain and other tissues.

Authors:  E M Cornford; W D Bocash; L D Braun; P D Crane; W H Oldendorf; A J MacInnis
Journal:  J Clin Invest       Date:  1979-06       Impact factor: 14.808

7.  5-Methoxyindoles in pineal gland of cow, pig, sheep and rat.

Authors:  O Beck; G Jonsson; A Lundman
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-12       Impact factor: 3.000

8.  Preliminary investigations of melatonin and 5-methoxy-tryptophol synthesis in the pineal, retina, and harderian gland of the mole rat and in the pineal of the mouse "eyeless".

Authors:  M G Balemans; P Pévet; W C Legerstee; E Nevo
Journal:  J Neural Transm       Date:  1980       Impact factor: 3.575

9.  Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKβ/NF-κB/COX-2 signaling pathway.

Authors:  Sandeep Shrestha; Jiabin Zhu; Qi Wang; Xiaohui Du; Fen Liu; Jianing Jiang; Jing Song; Jinshan Xing; Dongdong Sun; Qingjuan Hou; Yulin Peng; Jun Zhao; Xiuzhen Sun; Xishuang Song
Journal:  Int J Oncol       Date:  2017-08-22       Impact factor: 5.650

10.  Melatonin synergizes BRAF-targeting agent vemurafenib in melanoma treatment by inhibiting iNOS/hTERT signaling and cancer-stem cell traits.

Authors:  Jiaojiao Hao; Wenhua Fan; Yizhuo Li; Ranran Tang; Chunfang Tian; Qian Yang; Tianhua Zhu; Chaoliang Diao; Sheng Hu; Manyu Chen; Ping Guo; Qian Long; Changlin Zhang; Ge Qin; Wendan Yu; Miao Chen; Liren Li; Lijun Qin; Jingshu Wang; Xiuping Zhang; Yandong Ren; Penghui Zhou; Lijuan Zou; Kui Jiang; Wei Guo; Wuguo Deng
Journal:  J Exp Clin Cancer Res       Date:  2019-02-04
  10 in total

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