Literature DB >> 1425866

Simultaneous noninvasive evaluation of gastric emptying and orocaecal transit times. Use in studying the actions of cisapride in diabetic patients.

J F Bergmann1, O Chassany, P J Guillausseau, M Bayle, S Chagnon, C Caulin, J R Sallenave.   

Abstract

The aim of the study was to use a novel combination of two methods for the simultaneous evaluation of two effects of oral cisapride in 10 diabetic patients with autonomic neuropathy; gastric empyting time was measured by following radio-opaque markers and orocaecal transit time by the sulphasalazine-sulphapridine method. The study was of double-blind, randomized, placebo-controlled, cross-over design. It was possible to evaluate the effect of a prokinetic drug on gastric emptying and orocaecal transit times using these two noninvasive techniques at the same time. Cisapride significantly reduced both the gastric empyting (1.2 h versus 2.1 h) and orocaecal tansit (5.9 h versus 7.7 h) times.

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Year:  1992        PMID： 1425866     DOI： 10.1007/bf01740656

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  25 in total

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Journal:  Gut       Date:  1987-01       Impact factor: 23.059

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Journal:  Gut       Date:  1985-04       Impact factor: 23.059

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Journal:  Eur J Clin Pharmacol       Date:  1987       Impact factor: 2.953

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  5 in total

1.  Single oral dose of cisapride accelerates gastric antral emptying in healthy humans: an ultrasonographic study.

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Journal:  J Gastroenterol       Date:  1996-06       Impact factor: 7.527

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Authors:  L R Wiseman; D Faulds
Journal:  Drugs       Date:  1994-01       Impact factor: 9.546
  5 in total

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