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Literature DB >> 14256816

THE MECHANISM OF THE DEPRESSOR ACTION OF NORADRENALINE IN THE CAT.

Abstract

In cats anaesthetized with pentobarbitone sodium or chloralose and injected with phenoxybenzamine or phentolamine, administration of (-)-noradrenaline (5 to 20 mug) produced a fall of blood pressure which resembled in onset and duration that produced by adrenaline under similar conditions. The depressor action of noradrenaline was due mainly to dilatation of the splanchnic blood vessels. This could be abolished by administration of pronethalol, a drug known to block sympathetic beta-receptors.

Entities: Chemical Species

Keywords: BLOOD PRESSURE; CATS; CHLORALOSE; EXPERIMENTAL LAB STUDY; NOREPINEPHRINE; PENTOBARBITAL; PHARMACOLOGY; PHENOXYBENZAMINE; PHENTOLAMINE; PRONETHALOL; SYMPATHOLYTICS

Mesh：

Substances：

Year: 1964 PMID： 14256816 PMCID： PMC1704007 DOI： 10.1111/j.1476-5381.1964.tb01612.x

Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826

10 in total

9. Blood-pressure effects of noradrenaline and adrenaline with special reference to their antagonism by ergotoxine and other blocking agents.

Authors: K I MELVILLE
Journal: J Physiol Date: 1951-04 Impact factor: 5.182

10. The action of noradrenaline.

Authors: J H BURN; D E HUTCHEON
Journal: Br J Pharmacol Chemother Date: 1949-12

10 in total

6 in total

THE MECHANISM OF THE DEPRESSOR ACTION OF NORADRENALINE IN THE CAT.

1. EFFECT OF PRONETHALOL ON SOME INHIBITORY ACTIONS OF CATECHOLAMINES.

2. Pharmacology of a new adrenergic beta-receptor-blocking compound (Nethalide).

3. [Several adrenolytic drugs causing inversion of the hypertensive effects of adrenalin & noradrenalin in the rabbit].

4. The nature of the reflex vasodilatation induced by epinephrine.

5. The action of 5-hydroxytryptamine and tryptamine on aortic and carotid sinus receptors in the cat.

6. Adrenergic inhibitory function in the rabbit; epinephrine reversal and isopropylnorepinephrine vasodepression.

7. The presence of a sympathomimetic substance in extracts of mammalian heart.

8. Experiments on liver sympathin.

9. Blood-pressure effects of noradrenaline and adrenaline with special reference to their antagonism by ergotoxine and other blocking agents.

10. The action of noradrenaline.

1. Proceedings: The mechanism of "adrenaline reversal" in the anaesthetized cat and rabbit.

2. Effects of pronethalol on the cardiovascular actions of catecholamines during blockade by phenoxybenzamine.

3. The mechanism of the pressor action of noradrenaline in pithed cats.

4. Further observations on the pressor action of propranolol.

5. Effect of propranolol on alpha-adrenergic blockade in the dog and isolated rabbit aortic strip.

6. Unexpected hypotension in catecholamine reversal: a case report.