| Literature DB >> 14256805 |
Abstract
A possible relationship between stability of a tetracycline and persistence in the foetal skeleton is discussed; it seems that the greater the stability of a tetracycline, the more it may interfere with bone-forming processes. Therefore, assuming that limited instability does not impair antibiotic potency in vivo, the use of a low-stability tetracycline seems to be a safer form of treatment in order to avoid undesired effects on the foetal skeleton.Entities:
Keywords: ABNORMALITIES, DRUG-INDUCED; BONE DEVELOPMENT; CHELATING AGENTS; CHICK EMBRYO; CHLORTETRACYCLINE; DEMETHYLCHLORTETRACYCLINE; EXPERIMENTAL LAB STUDY; FETUS; FLUORESCENCE; TETRACYCLINE; TOXICOLOGIC REPORT
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Year: 1964 PMID： 14256805 PMCID： PMC1704013 DOI： 10.1111/j.1476-5381.1964.tb01601.x
Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826