Literature DB >> 14253479

ONSET AND DURATION OF DNA SYNTHESIS IN ANTIBODY FORMING CELLS AFTER ANTIGEN.

E P COHEN, D W TALMAGE.   

Abstract

Within 5 hours after the intravenous injection of particulate antigen into the primarily immunized mouse, precursors of antibody-forming cells began DNA synthesis as shown by the incorporation of tritium-labeled thymidine. DNA synthesis continued for at least 24 hours and essentially stopped by 48 hours. No DNA synthesis in antibody-forming precursor cells occurred before the injection of antigen.

Entities:  

Keywords:  ANTIBODY FORMATION; ANTIGEN-ANTIBODY REACTIONS; BCG VACCINATION; CELL NUCLEUS; DNA; EXPERIMENTAL LAB STUDY; METABOLISM; MICE; MICROSCOPY, FLUORESCENCE; RADIOAUTOGRAPHY; THYMIDINE; TRITIUM

Mesh：

Substances：

Year:  1965        PMID： 14253479      PMCID： PMC2137966          DOI： 10.1084/jem.121.1.125

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  7 in total

1.  THE EFFECT OF ENDOTOXIN ON THE ANTIBODY RESPONSE OF TRANSFERRED SPLEEN CELLS.

Authors:  E P COHEN; L K CROSBY; D W TALMAGE
Journal:  J Immunol       Date:  1964-02       Impact factor: 5.422

2.  Cellular proliferation in relation to antibody synthesis.

Authors:  R N BANEY; J J VAZQUEZ; F J DIXON
Journal:  Proc Soc Exp Biol Med       Date:  1962-01

3.  Agglutinin response, a function of cell number.

Authors:  E H PERKINS; M A ROBINSON; T MAKINODAN
Journal:  J Immunol       Date:  1961-05       Impact factor: 5.422

4.  The cellular basis for antibody formation.

Authors:  R W WISSLER; F W FITCH; M F LA VIA; C H GUNDERSON
Journal:  J Cell Physiol Suppl       Date:  1957-12

5.  Autoradiographic studies on the immune response.I. The kinetics of plasma cell proliferation.

Authors:  G J NOSSAL; O MAKELA
Journal:  J Exp Med       Date:  1962-01-01       Impact factor: 14.307

6.  Transformation of adult allogeneic small lymphocytes after transfusion into newborn rats.

Authors:  K A PORTER; E H COOPER
Journal:  J Exp Med       Date:  1962-05-01       Impact factor: 14.307

7.  Genetics of somatic mammalian cells. III. Long-term cultivation of euploid cells from human and animal subjects.

Authors:  T T PUCK; S J CIECIURA; A ROBINSON
Journal:  J Exp Med       Date:  1958-12-01       Impact factor: 14.307
  7 in total
  10 in total

1.  [Enhanced resistance of babymice to Variolavirus after active immunization with Vaccinia].

Authors:  V Hochstein-Mintzel; C Epp; A Herrlich
Journal:  Z Med Mikrobiol Immunol       Date:  1968

2.  Changes in the activities of uridine kinase and thymidine kinase in mouse spleen after immunization and passive transfer of specific antibodies.

Authors:  K Raska; J Rasková
Journal:  Clin Exp Immunol       Date:  1969-01       Impact factor: 4.330

3.  Time of appearance and distribution of cells capable of secondary immune response following primary immunization.

Authors:  T L Vischer; P Stastny
Journal:  Immunology       Date:  1967-06       Impact factor: 7.397

4.  Specific activity of several enzymes of nucleotide metabolism in mouse spleen after immunization.

Authors:  K Raska; E P Cohen
Journal:  Clin Exp Immunol       Date:  1967-09       Impact factor: 4.330

5.  Relationship of germinal centers in lymphoid tissue to immunological memory. II. The detection of primed cells and their proliferation upon cell transfer to lethally irradiated syngeneic mice.

Authors:  J D Wakefield; G J Thorbecke
Journal:  J Exp Med       Date:  1968-07-01       Impact factor: 14.307

6.  The effects of antigens and of phytohemagglutinin on rabbit spleen cell suspensions.

Authors:  G Harris; R J Littleton
Journal:  J Exp Med       Date:  1966-10-01       Impact factor: 14.307

7.  Cell populations and cell proliferation in the in vitro response of normal mouse spleen to heterologous erythrocytes. Analysis by the hot pulse technique.

Authors:  R W Dutton; R I Mishell
Journal:  J Exp Med       Date:  1967-09-01       Impact factor: 14.307

8.  Lymphoid cellular responses in the blood after immunization in man.

Authors:  D Crowther; G H Fairley; R L Sewell
Journal:  J Exp Med       Date:  1969-05-01       Impact factor: 14.307

9.  The carriage of immunological memory by small lymphocytes in the rat.

Authors:  J L Gowans; J W Uhr
Journal:  J Exp Med       Date:  1966-11-01       Impact factor: 14.307

10.  Antibody production in vitro. I. Single cell studies of the secondary response to sheep erythrocytes.

Authors:  G Harris
Journal:  J Exp Med       Date:  1968-04-01       Impact factor: 14.307
  10 in total

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