| Literature DB >> 14242035 |
C B HUGGINS, E FORD, E V JENSEN.
Abstract
Compared with other species, the rat is unusually vulnerable to polynuclear aromatic hydrocarbons. In the rat, relatively small amounts of carcinogenic aromatics (i) profoundly depress incorporation of thymidine in DNA, (ii) greatly induce menadione reductase in liver, and (iii) then kill the rat.Entities:
Keywords: ANIMALS, NEWBORN; BENZANTHRACENES; DNA; EXPERIMENTAL LAB STUDY; GLUCOSEPHOSPHATE DEHYDROGENASE; ISOCITRATE DEHYDROGENASE; LACTATE DEHYDROGENASE; MAMMARY NEOPLASMS, EXPERIMENTAL; METABOLISM; MICE; NEOPLASMS, EXPERIMENTAL; OXIDOREDUCTASES; PHARMACOLOGY; PHOSPHOGLUCONATE DEHYDROGENASE; RATS; RODENTS; SPECIES SPECIFICITY; TOXICOLOGIC REPORT; VITAMIN K
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Year: 1965 PMID： 14242035 DOI： 10.1126/science.147.3662.1153
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728