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Literature DB >> 14242034

PROTEIN SYNTHESIS INHIBITION: MECHANISM FOR THE PRODUCTION OF IMPAIRED FAT ABSORPTION.

Abstract

Treatment of rats with puromycin and acetoxycycloheximide results in a defect in intestinal lipid transport. Under these conditions rats given corn oil accumulate triglyceride within the intestinal cells and fail to develop the normal postprandial hyperlipemia. The observed interference in lipid transport appears to be a consequence of impaired chylomicron formation.

Entities: Chemical Disease Species

Keywords: CARBON ISOTOPES; CHYLOMICRONS; EXPERIMENTAL LAB STUDY; GLYCERIDES; INTESTINAL ABSORPTION; LIPID METABOLISM; MICROSCOPY, ELECTRON; PALMITIC ACID; PHARMACOLOGY; PROTEIN METABOLISM; PUROMYCIN; RATS

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Substances：

Year: 1965 PMID： 14242034 DOI： 10.1126/science.147.3662.1149

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

24 in total

1. Intestinal lipid absorption: evidence for an intrinsic defect of chylomicron secretion by normal rat distal intestine.

Authors: S M Sabesin; P R Holt
Journal: Lipids Date: 1975-12 Impact factor: 1.880

10. Effect of DL-ethionine on the intestinal absorption and transport of palmitic acid-1-14C and tripalmitin-14C. Role of intramucosal factors in the uptake of luminal lipids.

Authors: J I Kessler; S Mishkin; J Stein
Journal: J Clin Invest Date: 1969-08 Impact factor: 14.808

PROTEIN SYNTHESIS INHIBITION: MECHANISM FOR THE PRODUCTION OF IMPAIRED FAT ABSORPTION.

1. Intestinal lipid absorption: evidence for an intrinsic defect of chylomicron secretion by normal rat distal intestine.

2. Release of chylomicrons by isolated cells of rat intestinal mucosa.

3. Jejunal epithelium in transmissible gastroenteritis of swine. An electron microscopic and histochemical study.

Review 4. Present understanding of the interaction of drugs and food during absorption.

5. Transport of lipid across the small intestine.

Review 6. [Hereditary abnormalities in plasma lipids].

7. The effect of calcium ions on long chain fatty acid transport by slices of rat jejunum.

8. Effect of hydrophobic detergent on lipid absorption in the rat and on lipid and sterol balance in the swine.

9. Studies on the absorptive defect for triglyceride in abetalipoproteinemia.

10. Effect of DL-ethionine on the intestinal absorption and transport of palmitic acid-1-14C and tripalmitin-14C. Role of intramucosal factors in the uptake of luminal lipids.