Literature DB >> 14242025

MUTAGENICITY OF A MONOFUNCTIONAL ALKYLATING AGENT DERIVATIVE OF ACRIDINE IN NEUROSPORA.

H E BROCKMAN, W GOBEN.   

Abstract

Purple adenine (ad-3) mutants induced in Neurospora crassa by 2-methoxy-6-chloro-9-(3-[ethyl-2-chloroethyl] aminopropylamino) acridine dihydrochloride (ICR-170) result from intragenic alterations. They are further characterized by low frequencies of leakiness, allelic complementation, and nonpolarized complementation patterns. These characteristics distinguish them from ad-3 mutants induced by x-rays, nitrous acid, and 2-aminopurine.

Entities:  

Keywords:  ACRIDINES; ALKYLATING AGENTS; CHEMISTRY; EXPERIMENTAL LAB STUDY; MUTATION; NEUROSPORA; NITROGEN MUSTARD COMPOUNDS; PHARMACOLOGY

Mesh：

Substances：

Year:  1965        PMID： 14242025     DOI： 10.1126/science.147.3659.750

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  7 in total

1.  Sequencing studies of ICR-170 mutagenic specificity in the am (NADP-specific glutamate dehydrogenase) gene of Neurospora crassa.

Authors:  P A Burns; J H Kinnaird; B J Kilbey; J R Fincham
Journal:  Genetics       Date:  1986-05       Impact factor: 4.562

2.  Polarised complementation at the pyrimidine-3 locus of Neurospora.

Authors:  A Radford
Journal:  Mol Gen Genet       Date:  1969-07-03

3.  Genetic effects of N-methyl-N'-nitro-N-nitrosoguanidine in Neurospora crassa.

Authors:  H V Malling; F J De Serres
Journal:  Mol Gen Genet       Date:  1970

4.  Mutagenic activities of aflatoxin B 1 and G 1 in Neurospora crassa.

Authors:  T M Ong
Journal:  Mol Gen Genet       Date:  1971

5.  Evidence favoring a frame shift mechanism for ICR-170 induced mutations in Drosophila melanogaster.

Authors:  E A Carlson; R Sederoff; M Cogan
Journal:  Genetics       Date:  1967-02       Impact factor: 4.562

6.  Chromosomal rearrangements induced in Drosophila salivary gland chromosomes by an acridine half mustard.

Authors:  S Kumar; R P Sharma
Journal:  Experientia       Date:  1967-04-15

7.  Specific binding of o-phenanthroline at a DNA structural lesion.

Authors:  L D Williams; J Thivierge; I H Goldberg
Journal:  Nucleic Acids Res       Date:  1988-12-23       Impact factor: 16.971
  7 in total

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