Literature DB >> 14241408

POLYPEPTIDE CHAINS OF ANTIBODY: EFFECTIVE BINDING SITES REQUIRE SPECIFICITY IN COMBINATION.

O A ROHOLT, G RADZIMSKI, D PRESSMAN.   

Abstract

Separated chains from antibody of different rabbits do not always give effective binding sites although combination of the chains does occur. There is a specificity of combination such that only chains from the same (or perhaps a related) rabbit form effective binding sites. There appears to be preferential combination between those chains which yield effective sites.

Entities:  

Keywords:  ANTIBODIES; EXPERIMENTAL LAB STUDY; HAPTENS; PEPTIDES; RABBITS; ULTRACENTRIFUGATION

Mesh：

Substances：

Year:  1965        PMID： 14241408     DOI： 10.1126/science.147.3658.613

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  7 in total

1.  Recombination of heavy and light chains from human immunoglobulins.

Authors:  S Gordon; S Cohen
Journal:  Immunology       Date:  1966-06       Impact factor: 7.397

2.  Conformational change and complementarity in the combination of H and L chains of immunoglobulin-G.

Authors:  K J Dorrington; M H Zarlengo; C Tanford
Journal:  Proc Natl Acad Sci U S A       Date:  1967-09       Impact factor: 11.205

3.  The effect of the interaction of heavy and light chains of IgG on the Gm and Inv antigens.

Authors:  S H Polmar; A G Steinberg
Journal:  Biochem Genet       Date:  1967-09       Impact factor: 1.890

4.  The antigen-binding capacity of the peptide chains of horse antibodies.

Authors:  R C Weir; R R Porter
Journal:  Biochem J       Date:  1966-07       Impact factor: 3.857

5.  Preferential recombination of antibody chains to form effective binding sites.

Authors:  O A Roholt; G Radzimski; D Pressman
Journal:  J Exp Med       Date:  1965-10-01       Impact factor: 14.307

6.  Recovery of antibody activity from inactive hybrids of H and L chains.

Authors:  O A Roholt; G Radzimski; D Pressman
Journal:  J Exp Med       Date:  1967-01-01       Impact factor: 14.307

7.  Specificity in the combination of Fd fragments with L chains to form hapten-binding sites.

Authors:  O A Roholt; G Radzimski; D Pressman
Journal:  J Exp Med       Date:  1966-05-01       Impact factor: 14.307
  7 in total

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