Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 MECHANISM OF RESISTANCE TO ACTINOMYCIN IN BACILLUS SUBTILIS.

Literature DB >> 14240938

MECHANISM OF RESISTANCE TO ACTINOMYCIN IN BACILLUS SUBTILIS.

M POLSINELLI, O CIFERRI, G CASSANI, A ALBERTINI.

Abstract

Polsinelli, M. (University of Pavia, Pavia, Italy), O. Ciferri, G. Cassani, and A. Albertini. Mechanism of resistance to actinomycin in Bacillus subtilis. J. Bacteriol. 88:1567-1572. 1964.-Strains of Bacillus subtilis were rendered resistant to actinomycin D by serial transfer in increasing concentrations of the drug. Resistance to the antibiotic appeared to be due to an altered cell-wall permeability, because the resistant strains did not take up actinomycin. No evidence was found for the presence of an enzyme(s) degrading actinomycin. Deoxyribonucleic acid (DNA) extracted from the actinomycin-resistant strains was found to bind actinomycin to the same extent as the DNA extracted from susceptible strains. The genetic nature of the resistance to actinomycin was demonstrated by means of transformation. Resistant strains appeared to have almost completely lost their transformability, as well as the tendency to autolyze.

Entities: Chemical Species

Keywords: ACTINOMYCIN; BACILLUS SUBTILIS; CELL MEMBRANE PERMEABILITY; DNA, BACTERIAL; DRUG RESISTANCE, MICROBIAL; EXPERIMENTAL LAB STUDY; GENETICS; PHARMACOLOGY

Mesh：

Substances：

Year: 1964 PMID： 14240938 PMCID： PMC277453 DOI： 10.1128/jb.88.6.1567-1572.1964

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

17 in total

1. BIOCHEMICAL ASPECTS OF COMPETENCE IN THE BACILLUS SUBTILIS TRANSFORMATION SYSTEM. II. AUTOLYTIC ENZYME ACTIVITY OF CELL WALLS.

Authors: F E YOUNG; J SPIZIZEN
Journal: J Biol Chem Date: 1963-09 Impact factor: 5.157

2. Inhibition of protein synthesis in E. coli protoplasts by actinomycin-D.

Authors: A M HAYWOOD; R L SINSHEIMER
Journal: J Mol Biol Date: 1963-03 Impact factor: 5.469

3. Physiological and genetic factors affecting transformation of Bacillus subtilis.

Authors: F E YOUNG; J SPIZIZEN
Journal: J Bacteriol Date: 1961-05 Impact factor: 3.490

4. Linkage of genetic units of Bacillus subtilis in DNA transformation.

Authors: E W NESTER; J LEDERBERG
Journal: Proc Natl Acad Sci U S A Date: 1961-01-15 Impact factor: 11.205

5. [On the mode of action of actinomycins].

Authors: H M RAUEN; H KERSTEN; W KERSTEN
Journal: Hoppe Seylers Z Physiol Chem Date: 1960-12-02

6. The role of deoxyribonucleic acid in ribonucleic acid synthesis. III. The inhibition of the enzymatic synthesis of ribonucleic acid and deoxyribonucleic acid by actinomycin D and proflavin.

Authors: J HURWITZ; J J FURTH; M MALAMY; M ALEXANDER
Journal: Proc Natl Acad Sci U S A Date: 1962-07-15 Impact factor: 11.205

7. The basis of chloramphenicol resistance in Pseudomonas fluorescens.

Authors: D J KUSHNER
Journal: Arch Biochem Biophys Date: 1955-10 Impact factor: 4.013

8. Enzymatic basis of resistance to aureomycin. I. Differences between flavoprotein nitro reductases of sensitive and resistant Escherichia coli.

Authors: L M MARTINEZ; A K SAZ
Journal: J Biol Chem Date: 1956-11 Impact factor: 5.157

MECHANISM OF RESISTANCE TO ACTINOMYCIN IN BACILLUS SUBTILIS.

1. BIOCHEMICAL ASPECTS OF COMPETENCE IN THE BACILLUS SUBTILIS TRANSFORMATION SYSTEM. II. AUTOLYTIC ENZYME ACTIVITY OF CELL WALLS.

2. Inhibition of protein synthesis in E. coli protoplasts by actinomycin-D.

3. Physiological and genetic factors affecting transformation of Bacillus subtilis.

4. Linkage of genetic units of Bacillus subtilis in DNA transformation.

5. [On the mode of action of actinomycins].

6. The role of deoxyribonucleic acid in ribonucleic acid synthesis. III. The inhibition of the enzymatic synthesis of ribonucleic acid and deoxyribonucleic acid by actinomycin D and proflavin.

7. The basis of chloramphenicol resistance in Pseudomonas fluorescens.

8. Enzymatic basis of resistance to aureomycin. I. Differences between flavoprotein nitro reductases of sensitive and resistant Escherichia coli.

9. Action of actinomycin D on animal cells and viruses.

10. Mutants of Escherichia coli requiring methionine or vitamin B12.

1. A NONSPECIFIC INCREASE IN PERMEABILITY IN ESCHERICHIA COLI PRODUCED BY EDTA.

2. Transformability of streptomycin-resistant group H streptococci.

3. Accumulation of 14C-streptomycin by streptomycin-sensitive and streptomycin-resistant group H streptococci.

4. Relationship between competence for transfection and for transformation.