Literature DB >> 1423790

3-anilino-L-alanine, structural determination of UV-5, a contaminant in EMS-associated L-tryptophan samples.

Y Goda1, J Suzuki, T Maitani, K Yoshihira, M Takeda, M Uchiyama.   

Abstract

An aniline derivative which corresponds to UV-5 in the preceding paper was isolated from the case L-tryptophan sample associated with eosinophilia-myalgia syndrome (EMS). By spectroscopic analyses, the structure was identified as 3-anilinoalanine. The compound was optically active, and the stereochemistry of alanine moiety was determined as L, by comparing the specific rotation with a synthesized 3-anilino-L-alanine.

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Year:  1992        PMID: 1423790     DOI: 10.1248/cpb.40.2236

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN: 0009-2363            Impact factor:   1.645


  7 in total

1.  Identification of four metabolites of 3-(phenylamino)alanine, a constituent in L-tryptophan products implicated in eosinophilia-myalgia syndrome, in rats.

Authors:  J Adachi; T Mio; Y Ueno; T Naito; A Nishimura; S Fujiwara; K Sumino; Y Tatsuno
Journal:  Arch Toxicol       Date:  1994       Impact factor: 5.153

2.  Accumulation of 3-(phenylamino)alanine, a constituent in L-tryptophan products implicated in eosinophilia-myalgia syndrome, in blood and organs of the Lewis rats.

Authors:  J Adachi; M Gomez; C C Smith; E M Sternberg
Journal:  Arch Toxicol       Date:  1995       Impact factor: 5.153

3.  Subchronic toxicity of 3-phenylamino alanine, an impurity in L-tryptophan reported to be associated with eosinophilia-myalgia syndrome.

Authors:  F Sato; Y Hagiwara; Y Kawase
Journal:  Arch Toxicol       Date:  1995       Impact factor: 5.153

4.  Contaminants in L-tryptophan associated with eosinophilia myalgia syndrome.

Authors:  R H Hill; S P Caudill; R M Philen; S L Bailey; W D Flanders; W J Driskell; M L Kamb; L L Needham; E J Sampson
Journal:  Arch Environ Contam Toxicol       Date:  1993-07       Impact factor: 2.804

5.  Metabolism and distribution in the rat of peak E substance, a constituent in L-tryptophan product implicated in eosinophilia-myalgia syndrome.

Authors:  J Adachi; T Naito; Y Ueno; Y Ogawa; I Ninomiya; Y Tatsuno
Journal:  Arch Toxicol       Date:  1993       Impact factor: 5.153

Review 6.  Regulatory science of natural products.

Authors:  Yukihiro Goda
Journal:  J Nat Med       Date:  2022-07-23       Impact factor: 3.192

Review 7.  Analytical Chemistry of Impurities in Amino Acids Used as Nutrients: Recommendations for Regulatory Risk Management.

Authors:  Sachise Karakawa; Miro Smriga; Naoko Arashida; Akira Nakayama; Hiroshi Miyano
Journal:  Nutrients       Date:  2022-07-11       Impact factor: 6.706

  7 in total

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