Literature DB >> 1423504

A novel neuropeptide, pituitary adenylate cyclase-activating polypeptide (PACAP), in human intestine: evidence for reduced content in Hirschsprung's disease.

Z Shen1, L T Larsson, G Malmfors, A Absood, R Håkanson, F Sundler.   

Abstract

A novel neuropeptide, pituitary adenylate cyclase-activating polypeptide (PACAP), exhibits sequence homology with vasoactive intestinal polypeptide (VIP) and occurs in the mammalian brain, lung and gut. The distribution of PACAP in ganglionic and aganglionic portions of the large intestine of patients with Hirschsprung's disease was examined by immunohistochemistry and radioimmunoassay. PACAP-immunoreactive nerve fibers were distributed in all layers of the ganglionic and aganglionic segments of the intestine, although they were less numerous in the latter, and PACAP-immunoreactive nerve cell bodies were seen in the ganglionic portion of the intestine. The concentration of immunoreactive PACAP was lower in the aganglionic than in the ganglionic segment of the intestinal wall. PACAP and VIP were found to coexist in both ganglionic and aganglionic segments of the intestine. Apparently, PACAP participates in the regulation of gut motility. The scarcer PACAP innervation of the aganglionic segment may contribute to the defect in intestinal relaxation seen in patients with Hirschsprung's disease.

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Year:  1992        PMID： 1423504     DOI： 10.1007/bf00319630

Source DB:  PubMed          Journal:  Cell Tissue Res        ISSN： 0302-766X            Impact factor:   5.249


  29 in total

1.  Congenital megacolon; a comparison of the spastic and hypertrophied segments with respect to Cholinesterase activities and sensitivities to Acetylcholine, DFP and the barium ion.

Authors:  K KAMIJO; R B HIATT; G B KOELLE
Journal:  Gastroenterology       Date:  1953-06       Impact factor: 22.682

2.  A novel peptide which stimulates adenylate cyclase: molecular cloning and characterization of the ovine and human cDNAs.

Authors:  C Kimura; S Ohkubo; K Ogi; M Hosoya; Y Itoh; H Onda; A Miyata; L Jiang; R R Dahl; H H Stibbs
Journal:  Biochem Biophys Res Commun       Date:  1990-01-15       Impact factor: 3.575

3.  Increased neuropeptide Y-immunoreactive innervation of aganglionic bowel in Hirschsprung's disease.

Authors:  Y Hamada; A E Bishop; G Federici; M Rivosecchi; I C Talbot; J M Polak
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1987

4.  An immunochemical study with neuron-specific-enolase and substance P of human enteric innervation--the normal developmental pattern and abnormal deviations in Hirschsprung's disease and pyloric stenosis.

Authors:  P K Tam
Journal:  J Pediatr Surg       Date:  1986-03       Impact factor: 2.545

5.  Hirschsprung's disease: a comparison of the nervous control of ganglionic and aganglionic smooth muscle in vitro.

Authors:  L T Larsson; G Malmfors; C Wahlestedt; S Leander; R Håkanson
Journal:  J Pediatr Surg       Date:  1987-05       Impact factor: 2.545

6.  Adrenergic hyperactivity of the aganglionic colon.

Authors:  R J Touloukian; G Aghajanian; R H Roth
Journal:  J Pediatr Surg       Date:  1973-04       Impact factor: 2.545

7.  Immunohistochemical investigations of gut hormones in the colon of patients with Hirschsprung's disease.

Authors:  T Tsuto; H Okamura; K Fukui; H L Obata-Tsuto; H Terubayashi; J Yanagihara; N Iwai; S Majima; N Yanaihara; Y Ibata
Journal:  J Pediatr Surg       Date:  1985-06       Impact factor: 2.545

8.  A quantitative study of acetylcholine in Hirschsprung's disease.

Authors:  H Ikawa; J Yokoyama; Y Morikawa; A Hayashi; K Katsumata
Journal:  J Pediatr Surg       Date:  1980-02       Impact factor: 2.545

9.  Pituitary adenylate cyclase activating peptide: a novel vasoactive intestinal peptide-like neuropeptide in the gut.

Authors:  F Sundler; E Ekblad; A Absood; R Håkanson; K Köves; A Arimura
Journal:  Neuroscience       Date:  1992       Impact factor: 3.590

10.  Peptidergic innervation irregularities in Hirschsprung's disease. Immunohistochemistry--radioimmunoassay.

Authors:  T Taguchi; K Tanaka; K Ikeda; S Matsubayashi; N Yanaihara
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1983
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  9 in total

Review 1.  Hirschprung's disease.

Authors:  P B Sullivan
Journal:  Arch Dis Child       Date:  1996-01       Impact factor: 3.791

2.  Distribution of pituitary adenylyl cyclase activating peptide (PACAP) immunoreactivity in neurons of the guinea-pig digestive tract and their projections in the ileum and colon.

Authors:  A L Portbury; K McConalogue; J B Furness; H M Young
Journal:  Cell Tissue Res       Date:  1995-02       Impact factor: 5.249

Review 3.  Pituitary adenylate cyclase-activating polypeptide and islet amyloid polypeptide in primary sensory neurons: functional implications from plasticity in expression on nerve injury and inflammation.

Authors:  H Mulder; H Jongsma; Y Zhang; S Gebre-Medhin; F Sundler; N Danielsen
Journal:  Mol Neurobiol       Date:  1999-06       Impact factor: 5.590

4.  Electrophysiological analysis of the actions of pituitary adenylyl cyclase activating peptide in the taenia of the guinea-pig caecum.

Authors:  K McConalogue; D J Lyster; J B Furness
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-11       Impact factor: 3.000

5.  Role of PACAP1 receptor in regulation of ECL cells and gastric acid secretion by pituitary adenylate cyclase activating peptide.

Authors:  J R Pisegna; G V Ohning; C Athmann; N Zeng; J H Walsh; G Sachs
Journal:  Ann N Y Acad Sci       Date:  2000       Impact factor: 5.691

6.  Expression of pituitary adenylate cyclase-activating polypeptide and PACAP type 1 receptor in the rat gastric and colonic myenteric neurons.

Authors:  Marcel Miampamba; Patrizia M Germano; Selin Arli; Helen H Wong; David Scott; Yvette Taché; Joseph R Pisegna
Journal:  Regul Pept       Date:  2002-05-30

7.  Cloning and characterization of the signal transduction of four splice variants of the human pituitary adenylate cyclase activating polypeptide receptor. Evidence for dual coupling to adenylate cyclase and phospholipase C.

Authors:  J R Pisegna; S A Wank
Journal:  J Biol Chem       Date:  1996-07-19       Impact factor: 5.157

8.  Diabetes Affects the Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)-Like Immunoreactive Enteric Neurons in the Porcine Digestive Tract.

Authors:  Katarzyna Palus; Michał Bulc; Jarosław Całka; Łukasz Zielonka; Marcin Nowicki
Journal:  Int J Mol Sci       Date:  2021-05-27       Impact factor: 5.923

9.  The pituitary adenylate cyclase activating polypeptide type 1 receptor (PAC1-R) is expressed on gastric ECL cells: evidence by immunocytochemistry and RT-PCR.

Authors:  N Zeng; T Kang; R M Lyu; H Wong; Y Wen; J H Walsh; G Sachs; J R Pisegna
Journal:  Ann N Y Acad Sci       Date:  1998-12-11       Impact factor: 5.691
  9 in total

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