| Literature DB >> 14230912 |
Abstract
Warfarin sodium was compared with bishydroxycoumarin (Dicumarol) in 16 patients on long-term anticoagulant therapy. When the patients were changed from bishydroxycoumarin to warfarin sodium there was no improvement in control of their prothrombin times. It was found that 5 mg. of warfarin had slightly less effect than 50 mg. of bishydroxycoumarin. It was concluded that the drugs were equally effective in long-term anticoagulant therapy. The metabolism of the ingested drug was more important than absorption in determining the control of the patients' prothrombin times.Entities:
Keywords: BISHYDROXYCOUMARIN; DRUG THERAPY; PROTHROMBIN TIME; TOXICOLOGIC REPORT; WARFARIN
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Year: 1964 PMID： 14230912 PMCID： PMC1927585
Source DB: PubMed Journal: Can Med Assoc J ISSN： 0008-4409 Impact factor: 8.262