M J MacLean1, G P Biro. 1. Department of Physiology, Faculty of Medicine, University of Ottawa, Ontario.
Abstract
OBJECTIVE: To define the time course of changes in bloodflow and microsphere content at intervals between one and 28 days after surgical ligation of the circumflex coronary artery. SUBJECTS AND METHODS: After the ligation, pigs were assigned to six groups; all pigs in a group were reanesthetized at either one, three, seven, 14, 21 or 28 days post ligation to determine myocardial bloodflow distribution using radionuclide-labelled (15 +/- 2 microns) microspheres. RESULTS: Bloodflow to the infarct zone, 10 mins post ligation, was 7.3 +/- 1.4% of the normal flow. At one and three days post occlusion, infarct bloodflow was about 50% of the 'normal', declining after day 7 to between 20 and 25%. Bloodflow in the noninfarct zone was significantly elevated during the initial 14 days, declining thereafter to within the normal range. Microspheres in the infarct zone injected prior to the occlusion became concentrated and were diluted in the noninfarct zone; the ratio of infarct:noninfarct microsphere content rose progressively, reaching a 2.5-fold rise by day 28. CONCLUSIONS: The initial stages of infarct healing are associated with a marked rise in bloodflow with a subsequent fall. A more prolonged augmentation of flow is evident in the noninfarct zone. Microspheres are useful in estimating the relative magnitude of changes in the myocardium accompanying the healing (shrinkage) of the infarct and hypertrophy occurring in the noninfarct zone after a coronary occlusion.
OBJECTIVE: To define the time course of changes in bloodflow and microsphere content at intervals between one and 28 days after surgical ligation of the circumflex coronary artery. SUBJECTS AND METHODS: After the ligation, pigs were assigned to six groups; all pigs in a group were reanesthetized at either one, three, seven, 14, 21 or 28 days post ligation to determine myocardial bloodflow distribution using radionuclide-labelled (15 +/- 2 microns) microspheres. RESULTS: Bloodflow to the infarct zone, 10 mins post ligation, was 7.3 +/- 1.4% of the normal flow. At one and three days post occlusion, infarct bloodflow was about 50% of the 'normal', declining after day 7 to between 20 and 25%. Bloodflow in the noninfarct zone was significantly elevated during the initial 14 days, declining thereafter to within the normal range. Microspheres in the infarct zone injected prior to the occlusion became concentrated and were diluted in the noninfarct zone; the ratio of infarct:noninfarct microsphere content rose progressively, reaching a 2.5-fold rise by day 28. CONCLUSIONS: The initial stages of infarct healing are associated with a marked rise in bloodflow with a subsequent fall. A more prolonged augmentation of flow is evident in the noninfarct zone. Microspheres are useful in estimating the relative magnitude of changes in the myocardium accompanying the healing (shrinkage) of the infarct and hypertrophy occurring in the noninfarct zone after a coronary occlusion.
Authors: Nina W van der Hoeven; Gladys N Janssens; Guus A de Waard; Henk Everaars; Christopher J Broyd; Casper W H Beijnink; Peter M van de Ven; Robin Nijveldt; Christopher M Cook; Ricardo Petraco; Tim Ten Cate; Clemens von Birgelen; Javier Escaned; Justin E Davies; Maarten A H van Leeuwen; Niels van Royen Journal: JAMA Cardiol Date: 2019-08-01 Impact factor: 14.676