Literature DB >> 1422576

Endogenous noradrenaline release from guinea-pig isolated trachea is inhibited by activation of M2 receptors.

K Racké1, C Hey, I Wessler.   

Abstract

Overflow of endogenous noradrenaline (NA) from guinea-pig isolated tracheae was evoked by electrical field stimulation (3 Hz, 540 pulses). The muscarinic receptor agonist oxotremorine inhibited the evoked overflow of NA in a concentration-dependent manner (EC50 84 nM). Methoctramine, pirenzepine and p-fluoro-hexahydrosiladiphenidol (each 1 microM) shifted the concentration-response curves of oxotremorine to the right with apparent pA2 values of 7.60, 6.74 and 6.18, respectively. It is concluded that sympathetic nerve terminals in the guinea-pig trachea are endowed with inhibitory muscarinic M2 receptors.

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Year:  1992        PMID： 1422576      PMCID： PMC1907620          DOI： 10.1111/j.1476-5381.1992.tb14454.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  7 in total

1.  Characterization of endogenous noradrenaline release from intact and epithelium-denuded rat isolated trachea.

Authors:  K Racké; A Bähring; G Brunn; M Elsner; I Wessler
Journal:  Br J Pharmacol       Date:  1991-05       Impact factor: 8.739

2.  Evidence for prejunctional inhibitory muscarinic receptors on sympathetic nerves innervating guinea-pig trachealis muscle.

Authors:  Y D Pendry; J Maclagan
Journal:  Br J Pharmacol       Date:  1991-05       Impact factor: 8.739

Review 3.  Polymethylene tetramines: a new generation of selective muscarinic antagonists.

Authors:  C Melchiorre
Journal:  Trends Pharmacol Sci       Date:  1988-06       Impact factor: 14.819

4.  Evidence for inhibition of sympathetic neurotransmission by endogenously released acetylcholine in the guinea-pig trachea.

Authors:  Y D Pendry; J Maclagan
Journal:  Br J Pharmacol       Date:  1991-12       Impact factor: 8.739

5.  p-fluoro-hexahydro-sila-difenidol: the first M2 beta-selective muscarinic antagonist.

Authors:  G Lambrecht; R Feifel; B Forth; C Strohmann; R Tacke; E Mutschler
Journal:  Eur J Pharmacol       Date:  1988-07-26       Impact factor: 4.432

6.  Ultrastructural study of guinea pig tracheal smooth muscle and its innervation.

Authors:  T R Jones; M S Kannan; E E Daniel
Journal:  Can J Physiol Pharmacol       Date:  1980-08       Impact factor: 2.273

7.  Characterization of prejunctional muscarinic autoreceptors in the guinea-pig trachea.

Authors:  H Kilbinger; R Schneider; H Siefken; D Wolf; G D'Agostino
Journal:  Br J Pharmacol       Date:  1991-07       Impact factor: 8.739
  7 in total
  3 in total

1.  Effects of indomethacin on muscarinic inhibition of endogenous noradrenaline release from rat isolated trachea.

Authors:  K Racké; G Brunn; M Elsner; I Wessler
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-07       Impact factor: 3.000

2.  Muscarinic inhibition of endogenous noradrenaline release from rabbit isolated trachea: receptor subtype and receptor reserve.

Authors:  C Hey; I Wessler; K Racké
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-11       Impact factor: 3.000

3.  Characterization of the prejunctional muscarinic receptors mediating inhibition of evoked release of endogenous noradrenaline in rabbit isolated vas deferens.

Authors:  U Grimm; H Fuder; U Moser; H G Bümert; E Mutschler; G Lambrecht
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-01       Impact factor: 3.000
  3 in total

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