Literature DB >> 14224519

CALOTROPIN, A CYTOTOXIC PRINCIPLE ISOLATED FROM ASCLEPIAS CURASSAVICA L.

S M KUPCHAN, J R KNOX, J E KELSEY, J A SAENZRENAULD.   

Abstract

An alcoholic extract of Asclepias curassavica L., a plant widely used in folk medicine for treating cancer and warts, shows cytotoxic activity when tested in vitro against cells derived from human carcinoma of the nasopharynx. Systematic fractionation of the extract has led to isolation and characterization of calotropin as a cytotoxic principle. Calotropin is similar in structure to two cardiac glycosides recently shown to be responsible for the cytotoxicity of Apocynum cannabinum L.

Entities:  

Keywords:  ANTINEOPLASTIC AGENTS; CHEMISTRY, ANALYTICAL; EXPERIMENTAL LAB STUDY; MEXICO; PLANTS, MEDICINAL

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Substances：

Year:  1964        PMID： 14224519     DOI： 10.1126/science.146.3652.1685

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  7 in total

1.  Mosquitocidal properties of Calotropis gigantea (Family: Asclepiadaceae) leaf extract and bacterial insecticide, Bacillus thuringiensis, against the mosquito vectors.

Authors:  Kalimuthu Kovendan; Kadarkarai Murugan; Kanagarajan Prasanna Kumar; Chellasamy Panneerselvam; Palanisamy Mahesh Kumar; Duraisamy Amerasan; Jayapal Subramaniam; Savariar Vincent
Journal:  Parasitol Res       Date:  2012-03-02       Impact factor: 2.289

Review 2.  Recent progress in the biochemistry of plant steroids other than sterols (saponins, glycoalkaloids, pregnane derivatives, cardiac glycosides, and sex hormones).

Authors:  E Heftmann
Journal:  Lipids       Date:  1974-08       Impact factor: 1.880

3.  Plant poisons in a terrestrial food chain.

Authors:  L P Brower; J van Brower; J M Corvino
Journal:  Proc Natl Acad Sci U S A       Date:  1967-04       Impact factor: 11.205

4.  Chemopreventive potential of beta-Sitosterol in experimental colon cancer model--an in vitro and In vivo study.

Authors:  Albert A Baskar; Savarimuthu Ignacimuthu; Gabriel M Paulraj; Khalid S Al Numair
Journal:  BMC Complement Altern Med       Date:  2010-06-04       Impact factor: 3.659

5.  Ethnopharmacological survey among migrants living in the Southeast Atlantic Forest of Diadema, São Paulo, Brazil.

Authors:  Daniel Garcia; Marcus Vinicius Domingues; Eliana Rodrigues
Journal:  J Ethnobiol Ethnomed       Date:  2010-10-29       Impact factor: 2.733

Review 6.  A Review of Medicinal Plants of the Himalayas with Anti-Proliferative Activity for the Treatment of Various Cancers.

Authors:  Hailemeleak Regassa; Anuradha Sourirajan; Vikas Kumar; Sadanand Pandey; Deepak Kumar; Kamal Dev
Journal:  Cancers (Basel)       Date:  2022-08-12       Impact factor: 6.575

Review 7.  Oleandrin: A cardiac glycosides with potent cytotoxicity.

Authors:  Arvind Kumar; Tanmoy De; Amrita Mishra; Arun K Mishra
Journal:  Pharmacogn Rev       Date:  2013-07
  7 in total

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