RESPONSE OF CULTURED RABBIT CELLS TO INFECTION WITH THE SHOPE FIBROMA VIRUS. I. PROLIFERATION AND MORPHOLOGICAL ALTERATION OF THE INFECTED CELLS.

Hinze, Harry C. (University of Wisconsin, Madison), and Duard L. Walker. Response of cultured rabbit cells to infection with the Shope fibroma virus. I. Proliferation and morphological alteration of the infected cells. J. Bacteriol. 88:1185-1194. 1964.-Primary and serially cultured rabbit kidney cells were grown under conditions promoting rapid cell multiplication. When such cultures were infected with 5 to 10 plaque-forming units of Shope fibroma virus, cell multiplication was inhibited for a period of 2 to 3 days. After this stationary period, cell multiplication in the infected cultures was resumed at a rate approximating that of the uninfected controls. With the resumption of cell multiplication in the infected cultures, concurrent changes were observed in cell morphology and growth pattern. Cells showing such alterations also possessed the ability to form tumors when inoculated into the hamster cheek pouch.