DIHYDROSTREPTOMYCIN, VITAMIN K2-COUPLED TETRAZOLIUM REDUCTION, AND OXIDATIVE PHOSPHORYLATION IN ESCHERICHIA COLI.

Bragg, P. D. (University of British Columbia, Vancouver, B.C., Canada). Dihydrostreptomycin, vitamin K(2)-coupled tetrazolium reduction, and oxidative phosphorylation in Escherichia coli. J. Bacteriol. 88:1019-1023. 1964.-Dihydrostreptomycin inhibited the vitamin K(2)-coupled pyruvate-triphenyltetrazolium (TTC) reductase system in extracts from antibiotic-sensitive cells, but stimulated this reaction with extracts from a dependent mutant. The effects of nucleotides, phosphate, and uncoupling agents on the vitamin K(2)-TTC system are consistent with the linkage of reduction of the dye through intermediates of oxidative phosphorylation.