Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Identification of the O-linked glycosylation site of the human transferrin receptor.

Literature DB >> 1421757

Identification of the O-linked glycosylation site of the human transferrin receptor.

Abstract

The human transferrin receptor is a glycoprotein containing three N-linked and one O-linked glycosylation sites. Tryptic digestion of the receptor, followed by chromatography on BioGel P-2 and reverse-phase HPLC, yields a glycopeptide (amino acids 101-120) containing the O-linked site. Amino acid sequence analysis reveals that the site of O-glycosylation is Thr-104. Mass spectral analysis is consistent with the presence of a Gal-GalNAc core with predominantly two sialic acid residues.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1992 PMID： 1421757 DOI： 10.1093/glycob/2.4.355

Source DB: PubMed Journal: Glycobiology ISSN： 0959-6658 Impact factor: 4.313

Keyword Cloud
Cited

15 in total

1. Structural elucidation of O-linked glycopeptides by high energy collision-induced dissociation.

Authors: K F Medzihradszkyaff; B L Gillece-Castroaff; R R Townsendaff; A L Burlingameaff; M R Hardyaff
Journal: J Am Soc Mass Spectrom Date: 1996-04 Impact factor: 3.109

2. NetOglyc: prediction of mucin type O-glycosylation sites based on sequence context and surface accessibility.

Authors: J E Hansen; O Lund; N Tolstrup; A A Gooley; K L Williams; S Brunak
Journal: Glycoconj J Date: 1998-02 Impact factor: 2.916

3. The transmembrane domain of the molecular chaperone Cosmc directs its localization to the endoplasmic reticulum.

Authors: Qian Sun; Tongzhong Ju; Richard D Cummings
Journal: J Biol Chem Date: 2011-01-24 Impact factor: 5.157

4. Mining the O-glycoproteome using zinc-finger nuclease-glycoengineered SimpleCell lines.

Authors: Catharina Steentoft; Sergey Y Vakhrushev; Malene B Vester-Christensen; Katrine T-B G Schjoldager; Yun Kong; Eric Paul Bennett; Ulla Mandel; Hans Wandall; Steven B Levery; Henrik Clausen
Journal: Nat Methods Date: 2011-10-09 Impact factor: 28.547

Review 5. The acceptor specificity of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases.

Authors: A P Elhammer; F J Kézdy; A Kurosaka
Journal: Glycoconj J Date: 1999-02 Impact factor: 2.916

6. Prediction of O-glycosylation of mammalian proteins: specificity patterns of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase.

Authors: J E Hansen; O Lund; J Engelbrecht; H Bohr; J O Nielsen; J E Hansen
Journal: Biochem J Date: 1995-06-15 Impact factor: 3.857

Identification of the O-linked glycosylation site of the human transferrin receptor.

1. Structural elucidation of O-linked glycopeptides by high energy collision-induced dissociation.

2. NetOglyc: prediction of mucin type O-glycosylation sites based on sequence context and surface accessibility.

3. The transmembrane domain of the molecular chaperone Cosmc directs its localization to the endoplasmic reticulum.

4. Mining the O-glycoproteome using zinc-finger nuclease-glycoengineered SimpleCell lines.

Review 5. The acceptor specificity of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases.

6. Prediction of O-glycosylation of mammalian proteins: specificity patterns of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase.

7. Molecular evolution of the transferrin receptor/glutamate carboxypeptidase II family.

Review 8. CNS delivery via adsorptive transcytosis.

Review 9. The Cosmc connection to the Tn antigen in cancer.

Review 10. Novel Approaches and Challenges of Discovery of Exosite Modulators of a Disintegrin and Metalloprotease 10.