Literature DB >> 14216140

INCREASED SENSITIVITY TO HEPARIN FOLLOWING ACUTE MYOCARDIAL INFARCTION.

C DUFAULT.   

Abstract

In vivo increased sensitivity to heparin has been demonstrated in patients following an acute myocardial infarction. An intravenous injection of 10,000 units of heparin was given to each of 18 patients with recent myocardial infarction in order to compare them with 17 patients who were not suffering from any acute illness. The changes in whole blood clotting time, recalcified plasma clotting time and prothrombin time were greater and more prolonged in the patients with recent myocardial infarction. Of the three tests, the one-stage prothrombin time provided the simplest and the most precise measurement of heparin sensitivity. The reason for this was not clear: it is possible that it is related to shock and congestive heart failure which were complications of the clinical course following myocardial infarction.

Entities:  

Keywords:  BLOOD COAGULATION TESTS; CLINICAL RESEARCH; HEPARIN, THERAPEUTIC; MYOCARDIAL INFARCT; PROTHROMBIN TIME

Mesh：

Substances：

Year:  1965        PMID： 14216140      PMCID： PMC1927875     

Source DB:  PubMed          Journal:  Can Med Assoc J        ISSN： 0008-4409            Impact factor:   8.262


  9 in total

1.  CORONARY UNIT: AN INTENSIVE-CARE CENTRE FOR ACUTE MYOCARDIAL INFARCTION.

Authors:  K W BROWN; R L MACMILLAN; N FORBATH; F MELGRANO; J W SCOTT
Journal:  Lancet       Date:  1963-08-17       Impact factor: 79.321

2.  Heparin thrombin time and plasma proteins after major operations.

Authors:  H C GODAL; C FICHERA
Journal:  Acta Med Scand       Date:  1961-10

3.  Coagulability and thrombosis.

Authors:  L POLLER
Journal:  Clin Sci       Date:  1956-02       Impact factor: 6.124

4.  Studies on spontaneous variations in blood coagulability immediately following myocardial infarction.

Authors:  J L BEAUMONT; H CHEVALIER; J LENEGRE
Journal:  Am Heart J       Date:  1953-05       Impact factor: 4.749

5.  CHANGES IN BLOOD COAGULATION FOLLOWING CORONARY THROMBOSIS MEASURED BY THE HEPARIN RETARDED CLOTTING TEST (WAUGH AND RUDDICK TEST).

Authors:  J H Ogura; N R Fetter; M A Blankenhorn; H I Glueck
Journal:  J Clin Invest       Date:  1946-07       Impact factor: 14.808

6.  The response of the clotting equilibrium to postoperative stress.

Authors:  G DE TAKATS; M H MARSHALL
Journal:  Surgery       Date:  1952-01       Impact factor: 3.982

7.  A Test for Increased Coagulability of the Blood.

Authors:  T R Waugh; D W Ruddick
Journal:  Can Med Assoc J       Date:  1944-06       Impact factor: 8.262

8.  Acceleration of blood coagulation in acute myocardial infarction as demonstrated by the heparin clotting time; effect of dicumarol therapy.

Authors:  R L ROSENTHAL; J C WEAVER; A BENEDEK
Journal:  Circulation       Date:  1952-08       Impact factor: 29.690

9.  [Heparin tolerance test in vitro; hypocoagulability test, its application in diagnosis of hemorrhagic syndromes; hypercoagulability test, its application in the diagnosis of thrombosis].

Authors:  J P SOULIER; A G LE BOLLOCH
Journal:  Rev Hematol       Date:  1950
  9 in total

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