A CONTROLLED TRIAL OF LIVER-VIRUS VACCINE AGAINST MEASLES IN CHILE.

In view of the high mortality from measles in Chile, it was decided to undertake a double-blind, controlled trial of the Enders Edmonston B strain of live measles vaccine in that country as part of a WHO-sponsored programme to obtain information on reactions to that vaccine strain and on the antibody response elicited in children.Between July and December 1962, some 530 children 8 months to 3 years old received inoculations of vaccine, with or without gamma-globulin, or were given a placebo injection. The reactions were generally of moderate intensity and were not appreciably reduced in either frequency or intensity by gamma-globulin. Serological conversion was achieved in about 90% of the vaccinated.On the basis of this experience, it was decided to institute a large-scale immunization in Chile with the same vaccine; the campaign began in May 1963.

RCT Entities:   Population Interventions Outcomes