Literature DB >> 14214228

MURINE MAMMARY CARCINOMAS INDUCED BY INTRAVAGINAL APPLICATIONS OF METHYLCHOLANTHRENE IN MINIMAL DOSAGES.

Y H YANG, J S CAMPBELL.   

Abstract

Mammary cancer occurred in five of 80 ICR Swiss mice and two of 52 phenotypically normal pituitary dwarf strain mice following intravaginal applications of 20-methylcholanthrene in doses totalling 2.0 to 5.5 mg. Twenty-two of these 132 methylcholanthrene-treated mice had lower genital tract cancer. One acetone-treated Swiss mouse developed mammary cancer. No genital tract or mammary cancer occurred in mice receiving less than 2.0 mg. methylcholanthrene. The carcinogen was administered when mice were young; mammary cancers appeared between 65 and 167 days after methylcholanthrene application was begun. This study provides additional examples of carcinogenesis in organs remote from sites of carcinogen treatment with carcinogen doses close to threshold levels for treated tissues.

Entities:  

Keywords:  ADENOCARCINOMA; CARCINOGENS; EXPERIMENTAL LAB STUDY; MAMMARY NEOPLASMS, EXPERIMENTAL; METHYLCHOLANTHRENE; MICE; NEOPLASM ETIOLOGY; PATHOLOGY

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Substances：

Year:  1964        PMID： 14214228      PMCID： PMC1928293     

Source DB:  PubMed          Journal:  Can Med Assoc J        ISSN： 0008-4409            Impact factor:   8.262


  6 in total

1.  The evolution of mammary cancer induced in virgin female IF mice with minimal doses of locally-acting methylcholanthrene.

Authors:  G M BONSER
Journal:  J Pathol Bacteriol       Date:  1954-10

2.  Adenoacanthomas of ovary and uterus occuring as coexistent or sequential primary neoplasms.

Authors:  J S CAMPBELL; D MAGNER; P FOURNIER
Journal:  Cancer       Date:  1961 Jul-Aug       Impact factor: 6.860

3.  Effect of dose and hormones on tumor production in rats given emulsified 9, 10-dimethyl-1,2-benzanthracene intravenously.

Authors:  R P GEYER; J E BRYANT; V R BLEISCH; E M PEIRCE; F J STARE
Journal:  Cancer Res       Date:  1953-07       Impact factor: 12.701

4.  Response of mammary-tumor-agent-free strain DBA female mice to percutaneous application of methylcholanthrene.

Authors:  H B ANDERVONT; T B DUNN
Journal:  J Natl Cancer Inst       Date:  1950-02       Impact factor: 13.506

5.  Carcinogenesis: Mechanism and Criteria of Carcinogenic Activity.

Authors:  A Cantero
Journal:  Can Med Assoc J       Date:  1962-09-29       Impact factor: 8.262

6.  Chemical induction of breast tumours in mice of the C57B1 strain. The influence of pseudopregnancy, pregnancy and lactation on induction by methylcholanthrene.

Authors:  J MARCHANT
Journal:  Br J Cancer       Date:  1961-09       Impact factor: 7.640
  6 in total

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